Ch. 7: Disorders of Blood Cells Flashcards Preview

Pathology > Ch. 7: Disorders of Blood Cells > Flashcards

Flashcards in Ch. 7: Disorders of Blood Cells Deck (44):
1

erythropoetin is made where?

in the kidneys

2

reasons for anemia

1) failed production
2) Hemorrhage (blood loss)
3) hemolysis (destruction)

3

what is fibrinogen involved in?

clotting

4

what is immunoglobulins involved in?

immune reactions

5

what are beta globulins involved in?

transport; reactant proteins

6

what is albumin involved in?

transport; plasma osmotic pressure

7

WBC: phagocytosis; immune reactions

monocytes

8

WBC: immune reactions

lymphocytes

9

platelets come from

megakaryocytes

10

life span of RBCs

120 days; 3 months

11

granulocyte life span

~4 days

12

lymphocytes and monocyte life span

~7 days

13

platelets life span

~7 days

14

about how much more is hematocrit than hemoglobin?

3x as much

15

color is mostly what for microcytic?

hypochromic (pale)

16

chronic hemorrhage first produces anemia dure to what? then later?

1) hemorrhage
2) failed RBC production bc of iron deficiency

17

chronic hemorrhage first produces anemia dure to what? then later?

1) hemorrhage
2) failed RBC production bc of iron deficiency

18

excess RBC in blood

polycythemia (erythrocytosis)

19

low plasma volume (dehydration) or "stress" polycythemia

relative polycthemia

20

increased total body RBCs

absolute polycythemia

21

low white cell count

leukopenia

22

high white cell count

leukocytosis

23

leukopenia examples

neutropenia and lymphopenia

24

leukocytosis examples

neutrophilia and lymphocytosis

25

leukemoid reaction

>50,000 WBCs/mm^3

26

enlarged nodes

lymphadenopathy

27

inflamed nodes

lymphadenitis

28

malignant cells in blood and BM; usually no mass

leukemia

29

types of leukemia

acute (agressive) or chronic (indolent)

30

malignant cells in a discrete mass, usually no circulating cells in blood

lymphoma

31

malignant cells in a discrete mass, usually no circulating cells in blood

lymphoma

32

abnormally small 22 is called what? what is it involved with?

philadelphia chromosome; chronic myeloid leukemia (CML)

33

preleukemia syndrome

myelodysplasia

34

acute more ( ) cells; chronic more ( ) cells

immature; mature

35

lymphoid leukemias: most common malignancy of children, aggressive

ALL

36

lymphoid leukemias: older individuals, most common leukemia, indolent course

CLL/SLL

37

lymphomas: 10-30 yo, mediastinum and neck involved

Hodgkin

38

Hodgkin cure rate

75-90%

39

lymphomas: more aggressive but depends on the type (ex. follicular, diffuse, cell size)

Non-Hodgkin

40

lymphomas: more aggressive but depends on the type (ex. follicular, diffuse, cell size)

Non-Hodgkin

41

malignant cell of Hodgkin's Disease

Reed-Sternberg Cell

42

"punched out" lesions

multiple myeloma

43

overactice, often enlarged spleen

hypersplenism

44

tumor of the thymic epithelial cells

thymoma