Ch5_Microbial Infection Flashcards
A state of tissue destruction resulting from invasion of microorganism
Infection
▫️communicable
▫️non-communicable
Any microorganism that can cause disease ➡️ must be able to bind to human host cells
Pathogen
How does pathogens works?
▫️directly destroys host cells
▫️interferes host cells’ metabolic capabilities
▫️exposes host cell to toxins
Qualities that allow microorganism to promote a disease (PATHOGENICITY)
▫️virulence ▫️infectivity ▫️toxigenicity ▫️antigenicity ▫️antigenic variability ▫️pathogenic defense mechanisms
The majority of microorganism are harmless to humans and may even be beneficial to our lives ➡️ we could not survive w/o then:
▫️antibiotics
▫️insulin
▫️food industry: in bread making, yogurt, cheese
Sterile and nonsterile body components:
▫️Normal flora
▫️Sterile areas of body
The beneficial population of microbes (bacteria, viruses, Protozoa) that live in and on our bodies:
▫️nose, pharyx
▫️mouth, colon, rectum
▫️vagina
▫️distal urethra and perineum
Sterile areas of the body:
▫️blood, CSF ▫️lungs ▫️stomach ▫️uterus, Fallopian tubes, ovaries ▫️bladder and kidneys
Manifestation of infection could be:
▫️local
▫️systemic
LOCAL manifestation of infection:
▫️heat ▫️incapacitation ▫️pain ▫️edema ▫️redness ▫️lymphadenitis ▫️purulent exudate
SYSTEMIC manifestation of Infection:
▫️fever ▫️weakness ▫️headache ▫️malaise ▫️anorexia ▫️nausea
Four (4) main classes of microorganism:
▫️bacteria
▫️viruses
▫️Protozoa
▫️fungi
It is a single-felled organisms, do not require living tissue to survive, vary by size & shape, they divide by binary fission
Bacteria
Components of Bacteria:
▫️cell membrane (aka cell envelope)
▫️indiscreet nucleus (no nuclear membrane)
▫️cytosol ( has carbohydrates, ribosomes and proteins), (No ER, mitochondria, or other key organelles)
