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Pathophysiology for PN > Ch5_Microbial Infection > Flashcards

Flashcards in Ch5_Microbial Infection Deck (14)
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1

A state of tissue destruction resulting from invasion of microorganism

Infection
▫️communicable
▫️non-communicable

2

Any microorganism that can cause disease ➡️ must be able to bind to human host cells

Pathogen

3

How does pathogens works?

▫️directly destroys host cells
▫️interferes host cells' metabolic capabilities
▫️exposes host cell to toxins

4

Qualities that allow microorganism to promote a disease (PATHOGENICITY)

▫️virulence
▫️infectivity
▫️toxigenicity
▫️antigenicity
▫️antigenic variability
▫️pathogenic defense mechanisms

5

The majority of microorganism are harmless to humans and may even be beneficial to our lives ➡️ we could not survive w/o then:

▫️antibiotics
▫️insulin
▫️food industry: in bread making, yogurt, cheese

6

Sterile and nonsterile body components:

▫️Normal flora
▫️Sterile areas of body

7

The beneficial population of microbes (bacteria, viruses, Protozoa) that live in and on our bodies:

▫️nose, pharyx
▫️mouth, colon, rectum
▫️vagina
▫️distal urethra and perineum

8

Sterile areas of the body:

▫️blood, CSF
▫️lungs
▫️stomach
▫️uterus, Fallopian tubes, ovaries
▫️bladder and kidneys

9

Manifestation of infection could be:

▫️local
▫️systemic

10

LOCAL manifestation of infection:

▫️heat
▫️incapacitation
▫️pain
▫️edema
▫️redness
▫️lymphadenitis
▫️purulent exudate

11

SYSTEMIC manifestation of Infection:

▫️fever
▫️weakness
▫️headache
▫️malaise
▫️anorexia
▫️nausea

12

Four (4) main classes of microorganism:

▫️bacteria
▫️viruses
▫️Protozoa
▫️fungi

13

It is a single-felled organisms, do not require living tissue to survive, vary by size & shape, they divide by binary fission

Bacteria

14

Components of Bacteria:

▫️cell membrane (aka cell envelope)
▫️indiscreet nucleus (no nuclear membrane)
▫️cytosol ( has carbohydrates, ribosomes and proteins), (No ER, mitochondria, or other key organelles)