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Flashcards in Ch4 - Altered Immunity Deck (29)
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1

Group of inactive proteins circulating in blood (C1 to C9)
Help destroys pathogens in the body as well as enhances phagocytosis, chemotaxis and the inflammatory response.

Complement system

2

Complement system destroy microorganisms by two ways:

1. Mark cells for phagocytosis
2. Lysis due to cell membrane damage

3

A lymphocytes that patrol the blood and lymph.
▫️able to kill foreign cells, cancer cells, virus-infected cells without activation of the 3rd line of defense

🔺Natural Killer (NK) Cells

4

Main components involved in immunity:

1. antibodies and antigens
2. Macrophages
3. Lymphocytes

5

Markers that can induce an immune response (also known as an immunogens [lg]

Antigens

6

A specific mechanism for identification and removal of foreign material:

▫️immune cells
▫️lymphocytes
▫️macrophages

7

All immune cells originate from:

▫️bone marrow

8

_____ and ____ has role in the maturation of the cells

▫️bone marrow
▫️thymus

9

The primary cell in the immune response is the

have a specific function of recognizing and reacting with antigens in the body.

Lymphocytes
(termed immune competent cells)

10

this immunity develops when T lymphocytes w protein receptors on the cell surface recognizes antigens on the surface of target cells and directly destroy the invading antigens

Cell-mediated immunity

11

T-cells are primary effective against:

Viruses, fungal and protozoal infections, cancer cells and foreign cells such as transplants

12

Two subgroup of T cells works as marker s in patients with acquired immunodeficiency syndrome (AIDS)
These are important in T-cell activation

▫️T helper cells “CD4” - receptor in cell membrane that regulates all cells in immune system
▫️Killer T cells “CD8” -primarily cytotoxic

13

Cell responsible for humoral immunity through production of antibodies or immunoglobulins

Acts primarily against Bacteria

B Cells

14

these are lymphocytes distinct from T and B lymphocytes. They destroy, w/o any prior exposure and sensitization, tumor cells and cells infected by virus

Natural killer cells

15

Efficient, rapid antibody response to subsequent antigen recognition

🗯this is how immunization/vaccines work

Memory cells

16

Secretion of antibody/immunoglobulin (lg)

Plasma Cells

17

Specific cellular antigen destruction

▫️become activated to antigens that are found usually on body cells infected with virus or transformed by cancer

Cytotoxic T cell (CD8)

18

Activation of antigen-specific T cell

Secretes cytokines

🔺critical when turned off..HIV destroys T helper cells. Immunosuppression thru chemotherapy shuts down immune system.

Helper T cell (CD4)

19

also known as immunogens (lg)

Antigen - markers that can induce an immune response

20

free wander in tissue looking for foreign invaders. First thing in the immune system response
▫️secretes cytokines to activate T and B cells
▫️can destroy virus-infected cells or tumour cells when appropriately stimulated by T-cells
▫️act as antigen presenting cells

Macrophages

21

Activation of lymphocytes occur by exposure to ______ antigens

Non-self

22

Cell-mediated immunity (attack on infected cells)

transfer toxin to the affected cell and kill it off

Cytotoxic (killer) Cells

23

Humoral immunity (secretion of antibodies by plasma cells)

Secretes the antibody by plasma cells which binds to antigen

▫️does not secrete different types of antibodies usually secretes one antibody and bind to a matched antigen. complement protein does lysis

B cells

24

Bone marrow stem cell

Lymphoblasts

25

The surface receptor on T cells recognizes antigens that are “self” and “non self”, and directly bind to ______ antigens to destroy them

non self

26

Types of T Lymphocytes

1. T helper cells
2. T cytotoxic Cells
3. T suppressor Cells
4. T memory cells

27

Release cytokines that will suppress the activity of B cells and other T cells when antigen has been inactivated or destroyed.

Sometimes called T-regulator

T Suppressor Cells

28

Two types of responses occur in the development of humoral immunity:

1. Primary response: 1st antigen exposure. Lag period (1-2 wks)


2. Secondary response: some activated B cells produce memory cells

29

Acquired Immunity types

▫️ Natural active -

▫️artificial active -

▫️natural passive -

▫️artificial passive -