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Pathophysiology for PN > Tissue Healing And Repair > Flashcards

Flashcards in Tissue Healing And Repair Deck (23)
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1

Body organs and structures contain two functional types of tissues:

1. Parenchyma
2. Stroma

2

What is parenchyma? Stroma?

Parenchyma- functioning cells
Stroma - supporting connective tissue

3

The primary objective of healing process is to :

"fill the gap" - restore the structural continuity of the injured part

4

Secondary objective of healing process is :

Restore the functional continuity of the injured part

5

Injured tissue heal by:

1. Resolution if tissue damage is minimal
2. Regeneration of parenchymal cells
3. Replacement with connective tissue

6

The chemical mediators involved with the healing process are:

1. Chemo taxis and fibroblast recruitment
2. Proliferation of cells

7

This occurs in response to mild injury (small scratch, superficial injuries)

Resolution (repair)

8

Injured cells can _______ themselves if damage is minimal, or else are rapidly _____w/o much body interruption

Repair , replaced

9

🔹leaves little/no evidence of injury- injured cells are replaced w/ same cells - restoration of original structure and function

Regeneration

10

Ability to regenerate varies with cell type:

▫️labile cells - skin and mucous membranes
▫️stable cells - undergo mitosis as necessary
▫️permanent cells - amitotic

11

Non- regenerated parenchymal cells are replaced by a _____ scar (process also called fibrosis) when: ___, ____

🔵 CT
▫️extensive tissue damage occurred
▫️cells are amitotic

12

Wound healing and closure occur by ___ and ___ depending on the extent of tissue damage

Primary or secondary intention

13

small wound e.g. sutured surgical incision or paper cut

Primary intention

14

e.g. burns, large surface wounds - tissues have undergone greater loss of tissues and contamination

Secondary intention

15

Tissue healing consists of three phases:

1. Inflammation
2. Proliferation (repair, regeneration, replacement)
3. Remodelling

16

It begins at time of injury and is important for preparing the wound for healing

Phase 1 - inflammation

17

allows plasma and blood components to leak into injured area and start the clotting process

Vascular changes

18

Neutrophils are first to arrive, macrophages will follow - enter the area of injured tissue, digest and remove invading organisms, debris and other foreign matter

Cellular changes

19

▫️Usually begins w/n 2 to 3 days of injury and may last as long as 3 was
▫️granulation tissue is formed during this period
▫️healing by 2ndary intention

Phase II - proliferative phase

20

Produce collagen also produce growth factors to initiate angiogenesis

Fibroblasts (recruited by macrophages)

21

▫️consists of new blood vessels, proliferating fibroblasts, and residual inflammatory cells
▫️functions as the foundation of the scar tissue

Granulation tissue

22

▫️Scar tissue remodels by breaking down old collagen (collagenase) and synthesizing new collagen (by fibroblasts) - increase tensile strength

Phase III - remodelling phase

23

Injuries that heal by 2ndary intention undergo ________

Wound contraction