Tissue Healing And Repair Flashcards Preview

Pathophysiology for PN > Tissue Healing And Repair > Flashcards

Flashcards in Tissue Healing And Repair Deck (23)
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1
Q

Body organs and structures contain two functional types of tissues:

A
  1. Parenchyma

2. Stroma

2
Q

What is parenchyma? Stroma?

A

Parenchyma- functioning cells

Stroma - supporting connective tissue

3
Q

The primary objective of healing process is to :

A

“fill the gap” - restore the structural continuity of the injured part

4
Q

Secondary objective of healing process is :

A

Restore the functional continuity of the injured part

5
Q

Injured tissue heal by:

A
  1. Resolution if tissue damage is minimal
  2. Regeneration of parenchymal cells
  3. Replacement with connective tissue
6
Q

The chemical mediators involved with the healing process are:

A
  1. Chemo taxis and fibroblast recruitment

2. Proliferation of cells

7
Q

This occurs in response to mild injury (small scratch, superficial injuries)

A

Resolution (repair)

8
Q

Injured cells can _______ themselves if damage is minimal, or else are rapidly _____w/o much body interruption

A

Repair , replaced

9
Q

🔹leaves little/no evidence of injury- injured cells are replaced w/ same cells - restoration of original structure and function

A

Regeneration

10
Q

Ability to regenerate varies with cell type:

A

▫️labile cells - skin and mucous membranes
▫️stable cells - undergo mitosis as necessary
▫️permanent cells - amitotic

11
Q

Non- regenerated parenchymal cells are replaced by a _____ scar (process also called fibrosis) when: ___, ____

A

🔵 CT
▫️extensive tissue damage occurred
▫️cells are amitotic

12
Q

Wound healing and closure occur by ___ and ___ depending on the extent of tissue damage

A

Primary or secondary intention

13
Q

small wound e.g. sutured surgical incision or paper cut

A

Primary intention

14
Q

e.g. burns, large surface wounds - tissues have undergone greater loss of tissues and contamination

A

Secondary intention

15
Q

Tissue healing consists of three phases:

A
  1. Inflammation
  2. Proliferation (repair, regeneration, replacement)
  3. Remodelling
16
Q

It begins at time of injury and is important for preparing the wound for healing

A

Phase 1 - inflammation

17
Q

allows plasma and blood components to leak into injured area and start the clotting process

A

Vascular changes

18
Q

Neutrophils are first to arrive, macrophages will follow - enter the area of injured tissue, digest and remove invading organisms, debris and other foreign matter

A

Cellular changes

19
Q

▫️Usually begins w/n 2 to 3 days of injury and may last as long as 3 was
▫️granulation tissue is formed during this period
▫️healing by 2ndary intention

A

Phase II - proliferative phase

20
Q

Produce collagen also produce growth factors to initiate angiogenesis

A

Fibroblasts (recruited by macrophages)

21
Q

▫️consists of new blood vessels, proliferating fibroblasts, and residual inflammatory cells
▫️functions as the foundation of the scar tissue

A

Granulation tissue

22
Q

▫️Scar tissue remodels by breaking down old collagen (collagenase) and synthesizing new collagen (by fibroblasts) - increase tensile strength

A

Phase III - remodelling phase

23
Q

Injuries that heal by 2ndary intention undergo ________

A

Wound contraction