Chap 44 Flashcards Preview

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Flashcards in Chap 44 Deck (15):
1

Done nomogram

A standard data graph, originally published in 1960 in the journal Pediatrics for rating the severity of aspirin toxicity following overdose. Serum salicylate levels are plotted against time elapsed since ingestion

2

Gout

Hyperuricemia (elevated blood uric acid level); the arthritis caused by tissue buildup of uric acid crystals

3

Inflammation

A localized protective response stimulated by injury to tissues that serves to destroy, dilute, or wall off (sequester) both the injurious agent and the injured tissue

4

Nonsteroidal antiinflammatory drugs (NSAIDS)

A large and chemically diverse group of drugs that possess analgesic, antiinflammatory, and antipyretic (fever-reducing) activity

5

Salicylism

The syndrome of salicylate toxicity, including symptoms such as tinnitus (ringing sound in the ears), nausea and vomiting

6

Allopurinol

Relief of gout by inhibiting the enzyme xanthine oxidase, preventing uric acid production

7

Aspirin

Used to treat pain associated with HA, neuralgia, myalgia, and arthralgia, and inflammation. Also, used prophylactically for pt's at risk for CAD and stroke

8

Aspirin special contraindication

Contraindicated in children with flulike symptoms, because the use of these drugs has been strongly associated with Reye's syndrome

9

Celecoxib

TX of osteoarthritis, RA, acute pain sx, ankylosing spondylitis, and primary dysmenorrhea. Not to be used in patients with sulfa allergy

10

Allopurinol (Zyloprim) Mechanism of Action

Inhibition of the enzyme xanthine oxidase, which thereby prevents uric acid production
Antigout drug

11

Aspirin Mechanism of Action

Inhibition of the leukotriene pathway, the prostaglandin pathway or both
Relieve pain, headache and inflammation by blocking the chemical activity of the enzyme cyclooxygenase (COX-1: promotes the synthesis of prostaglandins & COX-2: promotes synthesis of prostaglandins that are involved in inflammatory process, beneficial antiinflammatory effects with reduced prevalence of adverse effects)
Inhibition of platelet aggregation (antiplatelet activity): irreversible inhibitor of COX-1 receptors within the platelets themselves
Salicylate

12

Celecoxib (Celebrex) Mechanism of Action

Inhibition of the leukotriene pathway, the prostaglandin pathway or both
Relieve pain, headache and inflammation by blocking the chemical activity of the enzyme cyclooxygenase (COX-2: promotes synthesis of prostaglandins that are involved in inflammatory process, beneficial antiinflammatory effects with reduced prevalence of adverse effects)
Cyclooxygenase-2 (COX-2) Inhibitor

13

Ibuprofen (Motrin, Advil) Mechanism of Action

Inhibition of the leukotriene pathway, the prostaglandin pathway or both
Relieve pain, headache and inflammation by blocking the chemical activity of the enzyme cyclooxygenase (COX-1: promotes the synthesis of prostaglandins & COX-2: promotes synthesis of prostaglandins that are involved in inflammatory process, beneficial antiinflammatory effects with reduced prevalence of adverse effects)
Propionic acid derivative

14

Indomethacin Mechanism of Action

Inhibition of the leukotriene pathway, the prostaglandin pathway or both
Relieve pain, headache and inflammation by blocking the chemical activity of the enzyme cyclooxygenase (COX-1: promotes the synthesis of prostaglandins & COX-2: promotes synthesis of prostaglandins that are involved in inflammatory process, beneficial antiinflammatory effects with reduced prevalence of adverse effects)
Acetic acid derivative

15

Ketorolac (Toradol) Mechanism of Action

Inhibition of the leukotriene pathway, the prostaglandin pathway or both
Relieve pain, headache and inflammation by blocking the chemical activity of the enzyme cyclooxygenase (COX-1: promotes the synthesis of prostaglandins & COX-2: promotes synthesis of prostaglandins that are involved in inflammatory process, beneficial antiinflammatory effects with reduced prevalence of adverse effects)
Acetic acid derivative- Some antiinflammatory activity, powerful analgesic effects