Chap 42 Flashcards Preview

Pharmacology > Chap 42 > Flashcards

Flashcards in Chap 42 Deck (11):
1

Antimetabolite

A drug that is either a receptor antagonist or that resembles a normal human metabolite and interferes with its function in the body, usually by competing for the metabolite's usual receptors or enzymes

2

Dermatophyte

One of several fungi that are often found in soil and infect the skin, nails, or hair of humans

3

Ergosterol

The main sterol in fungal membranes

4

Fungi

A very large, diverse group of eukaryotic microorganisms that require an external carbon source and that form a plant structure known as a thallus. Fungi consist of yeasts and molds

5

Molds

Multicellular fungi characterized by long, branching filaments called hyphae, which entwine to form a complex branched structure known as a mycelium

6

Mycosis

The general term for any fungal infection

7

Pathologic fungi

Fungi that causes mycoses

8

Sterols

substances in the cell membranes of fungi to which polyene antifungal drugs bind

9

Yeasts

Single celled fungi that reproduce by budding

10

amphotericin (Fungizone) Mechanism of Action

Act by binding to sterols (main sterol is erogsterol) in the cell membranes of fungi
Channel forms in the fungal cell membrane that allows potassium and magnesium ions to leak out of the fungal cell
Causes fungal cellular metabolism to be altered, which leads to death of the cell

11

fluconazole (Diflucan) Mechanism of Action

Acts as either fungistatic or fungicidal drugs, depending on their concentration in the fungus
Most effective in combating rapidly growing fungi
Work by inhibiting fungal cell cytochrome P-450 enzymes (needed to produce ergosterol)
Methysterols are produced instead, defect in cell membrane making it leaky
Fungal cells die because they cannot carry on cellular metabolism