Chap 41 Flashcards Preview

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Flashcards in Chap 41 Deck (11):
1

Aerobic

Requiring oxygen for the maintenance of life

2

Antitubercular drugs

Drugs used to treat infections caused by Mycobacterium bacterial species

3

Bacillus

A rod shaped bacterium

4

Granulomas

Small nodular aggregations of inflammatory cells (e.g., macrophages, lymphocytes); usually characterized by clearly delimited boundaries, as found in tuberculosis

5

Isoniazid

The primary and most commonly prescribed tuberculostatis drug

6

Multidrug-resistant tuberculosis (MDR-TB)

Tuberculosis that demonstrates resistance to two or more drugs

7

Slow acetylator

An individual with a genetic defect that causes a deficiency in the enzyme needed to metabolize isoniazid, the most widely used tuberculosis drug

8

Tubercle

The characteristic lesion of tuberculosis; a small round gray translucent granulomatous lesion, usually with a caseated (cheesy) consistency in its interior

9

Tubercle bacilli

Another common name for rod-shaped tuberculosis bacteria; essentially synonymous with Mycobacterium tuberculosis

10

Tuberculosis (TB)

Any infectious disease caused by species of Mycobacterium, usually Mycobacterium tuberculosis (adjectives: tuberculous, tubercular)

11

Isoniazid (INH) Mechanism of Action

Act on the MTB by inhibit the synthesis of wall components (partly)
Taken up by mycobacterial cells & undergoes hydrolysis to isonicotinic acid, which reacts with cofactor NAD to form a defective NAD that is no longer active as a coenzyme for certain life sustaining reactions in Mycobacterium tuberculosis organism