Chapter 9 (Pt. 2)

Question 1

What type of drugs have few effective agents because of similarity in fungal and human cells?

Answer 1

Antifugal Drugs

Question 2

Are drugs combined to treat superficial mycoses?

Answer 2

Yes

Question 3

How do you treat superficial mycoses?

Answer 3

topical and oral

Question 4

What do superficial mycoses disrupt?

Answer 4

membrane permeability
sterol synthesis
mitotic spindle

Question 5

What mycoses is hard to control and can be fatal?

Answer 5

systemic mycoses

Question 6

What common drugs are used to treat systemic mycoses?

Answer 6

amphotericin B
5-flucytosine
fluconazole

Question 7

Why is drug development slow for antiviral drugs?

Answer 7

targeting viral replication is hard

Question 8

What do current antiviral drugs inhibit?

Answer 8

enzymes and life cycles

Question 9

What antiviral drugs treat influenza?

Answer 9

Amantidine

Tamiflu

Question 10

What is the difference between Amantidine and Tamiflu?

Answer 10

Amantidine uncoats influenza virus and Tamiflu inhibits neruaminidase

Question 11

What antiviral drugs treat herpes?

Answer 11

Acyclovir
Adenine arabinoside
Valacyclovir
Ganciclovir
Foscarnet

Question 12

What does Acyclovir (herpes) and Foscarnet inhibit?

Answer 12

DNA polymerase of virus

Question 13

What does Adenine arabinoside (herpes) inhibit?

Answer 13

enzymes involved in DNA and RNA synthesis

Question 14

What are the broad spectrum antiviral drugs?

Answer 14

HPMPC

Question 15

What does HPMPC inhibit?

Answer 15

DNA polymerase

Question 16

What are anti-HIV drugs?

Answer 16

Reverse transcriptase inhibitors
Protease inhibitors
Fusion inhibitors

Question 17

What do reverse transcriptase inhibitors do?

Answer 17

inhibit RT

Question 18

What do protease inhibitors do?

Answer 18

mimic peptide bonds

Question 19

What do fusion inhibitors do?

Answer 19

prevent HIV entry into cells

Question 20

Are HIV drugs served best as cocktails?

Answer 20

Yes

Question 21

What does research say about anti protozoan drugs?

Answer 21

mechanism are not precisely known

Question 22

What influences antimicrobial drugs?

Answer 22

ability of drug to reach the site, susceptibility of pathogen, and ability of drug to reach concentrations higher than the MIC of the pathogen

Question 23

What are the different ways drugs can reach the site of infection?

Answer 23

oral, topical, and parenteral

Question 24

What are factors that influence ability of drug to reach concentrations exceeding the MID?

Answer 24

amount administered
route of administration
speed of uptake
rate of clearance from the body

Question 25

What is an increasing problem in drug resistance?

Answer 25

resistance can be transferred from one population to another

Question 26

How do you overcome drug resistance?

Answer 26

Appropriate amounts Give two or more Use drugs only when necessary