CHARACTERISTICSOF LLM

Question 1

WHAT ARE THE PROLIFERATIVE DISORDERS (2)

Answer 1

MYELOID

LYMPHOID

Question 2

IS A DISEASE IN PERIPHERAL BLOOD AND BONE MARROW AND OVERPRODUCTION OF VARIOUS TYPES OF MATURE OR IMMATURE LEUKOCYTES

Answer 2

LEUKEMIA

Question 3

GENERAL TERM FOR SOLID MALIGNANT TUMORS OF LYMPH NODES

Answer 3

LYMPHOMA

Question 4

IS A FORM OF CANCER FROM PLASMA CELLS AND THE CELLS OVERGROW,FORMING A MASS OR TUMOR LOCATED IN THE BONE MARROW AND OVERPRODUCTION OF PLASMA CELLS IN BONE MARROW WITH PRODUCTION OF ABNORMAL PROTEINS

Answer 4

MYELOMA

Question 5

WHAT ARE THE HEMATOLOGICAL MALIGNANCIES (3)

Answer 5

LEUKEMIA

LYMPHOMA

MYELOMA

Question 6

WHAT ARE THE MARROW FAILURE (2)

Answer 6

APLASTIC ANEMIA

MYELODYSPLASIA

Question 7

WHAT ARE THE CONDITIONS OF MAJOR MYELOPROLIFERATIVE NEOPLASM (MPNs)IN WHO CLASSIFICATION (5)

Answer 7

CHRONIC MYELOID LEUKEMIA (CML)

POLYCYTHEMIA VERA (PV)

ESSENTIAL THROMBOCYTHEMIA (ET)

PRIMARY MYELOFIBROSIS (PMF)

Question 8

WHAT ARE THE CONDITIONS OF LEUKEMIA (4)

Answer 8

CHRONIC MYELOID LEUKEMIA (CML)

CHRONIC LYMPHOCYTIC LEUKEMIA (CLL)

ACUTE MYELOID LEUKEMIA (AML)

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Question 9

2 TYPES OF ACUTE LYMPHOBLASTIC LEUKEMIA

Answer 9

B CELL ACUTE LYMPHOCYTIC LEUKEMIA (B-ALL)

&

T CELL ACUTE LYMPHOCYTIC LEUKEMIA (T-ALL)

Question 10

WHAT ARE THE 4 TYPES OF B CELL ACUTE LYMPHOCYTIC LEUKEMIA

Answer 10

PRE-CURSER B CELL ACUTE LYMPHOCYTIC LEUKEMIA

PRO B-ALL B CELL ACUTE LYMPHOCYTIC LEUKEMIA

MATURE B CELL ACUTE LYMPHOCYTIC LEUKEMIA

COMMON B CELL ACUTE LYMPHOCYTIC LEUKEMIA

Question 11

WHAT ARE THE 2 TYPES OF LYMPHOMA

Answer 11

HODGKIN LYMPHOMA

NON-HODGKIN LYMPHOMA

Question 12

WHAT ARE THE TYPES OF HODGKIN LYMPHOMA (2)

Answer 12

CLASSICAL HODGKIN LYMPHOMA

NON-CLASSICAL HODGKIN LYMPHOMA

Question 13

CONDITION OF CLASSICAL HODGKIN LYMPHOMA (4)

Answer 13

NODULAR SCLEROSING

MIXED CELLULARITY

LYMPHOCYTE RICH

LYMPHOCYTE DEPLETED

Question 14

CONDITION OF NON CLASSICAL HODGKIN LYMPHOMA (1)

Answer 14

NODULAR LYMPHOCYTE-PREDOMINANT

Question 15

CONDITIONS OF B CELL NON HODGKIN LYMPHOMA (6)

Answer 15

BURKITT LYMPHOMA

DIFFUSE LARGE B-CELL LYMPHOMA

FOLLICULAR LYMPHOMA

MANTLE CELL LYMPHOMA

MARGINAL ZONE LYMPHOMA

PRIMARY CNS LYMPHOMA

Question 16

WHAT ARE THE 2 TYPES OF NON-HODGKIN LYMPHOMA

Answer 16

B CELL NON HODGKIN LYMPHOMA

T CELL NON HODGKIN LYMPHOMA

Question 17

CONDITIONS OF T CELL NON HODGKIN LYMPHOMA (2)

Answer 17

ADULT T CELL LYMPHOMA

MYCOSIS FUNGOIDES

Question 18

clonal hematopoietic stem cell disorders caused by genetic mutations leading to abnormal proliferation and accumulation of erythrocytes, granulocytes, and/or platelets.

Answer 18

MYELOPROLIFERATIVE NEOPLASMS

Question 18

WHAT ARE THE OTHER WHO RECOGNIZED MYELOPROLIFERATIVE NEOPLASMS (4)

Answer 18

CHRONIC NEUTROPHILIC LEUKEMIA (CNL)

CHRONIC EOSINOPHILIC LEUKEMIA (CEL)

MASTOCYTOSIS

MYELOPROLIFERATIVE NEOPLASM UNCLASSIFIED

Question 19

PATHOGENESIS OF MYELOPROLIFERATIVE NEOPLASM

Caused by _________ or _______ from normal cytokine regulation.

Affects _______, _______, and other _____ variably.

Answer 19

HYPERSENSITIVITY OR INDEPENDENCE

BONE MARROW, PERIPHERAL BLOOD AND TISSUES

Question 20

IS A STABE CHRONIC DISORDER

Progress to ________

Enter a _____ or ______ phase (marrow failure).

Transition through _____phases to more aggressive stages.

Answer 20

ACUTE LEUKEMIAS

DEPLETED OR HYPOPLASTIC

SUBACUTE

Question 21

Occur in families with multiple affected members, indicating possible inherited predisposition.

Answer 21

FAMILIAL MYELOPROLIFERATIVE NEOPLASMS

Question 22

caused by a single genetic translocation in a pluripotent hematopoietic stem cell.

Answer 22

MYELOPROLIVERATIVE NEOPLASM (MPN)

Question 23

Characterized by the _________ resulting from t(__,__)(__,__) translocation, creating the ________ fusion gene.

Answer 23

CHRONIC MYELOGENOUS LEUKEMIA

PHILADELPHIA CHROMOSOME

t(9,22) and q(34) q(11)

BCR-ABL1

Question 24

3 PHASES OF CHRONIC MYELOGENOUS LEUKEMIA

Answer 24

CHRONIC PHASE (INITIAL STAGE) ACCELERATED PHASE ( AFTER 3-4 YEARS IF UNTREATED) BLAST CRISIS (RESEMBLES ACUTE LEUKEMIA)

Question 25

CHRONIC MYELOGENOUS LEUKEMIA OCCURS IN ADULT AGED ______ SLIGHT ____PREDOMINANCE PRE-IMATINIB RATE: ____DEATHS PER _______/YEAR

Answer 25

46-53 YEARS OLD MALE 1.5; 100,000

Question 26

SIGN & SYMPTOMS OF CHRONIC MYELOGENOUS LEUKEMIA (6)

Answer 26

FATIGUE REDUCED EXERCISE TOLERANCE ANOREXIA WEIGHT LOSS ABDOMINAL DISCOMFORT SYMPTOMS DUE TO SPLENOMEGALY

Question 27

IS A CLONAL MYELOPROLIFERATIVE NEOPLASM (MPN). Characterized by ________ (increased erythrocytes, granulocytes, and platelets in blood). Arises from a __________. __________ cells in PV are _______ to or ______ of erythropoietin (EPO). Common clinical finding: _______.

Answer 27

POLYCYTHEMIA VERA PANMYELOSIS HEMATOPOIETIC STEM CELL SPLENOMEGALY ERYTHROID PROGENITOR; HYPERSENSITIVITY OR INDEPENDENT

Question 28

Discovered in _____, found in 90–97% of PV patients. Mutation in exon 14: _____ → _____ causing ______to be replaced by _____ at ______ Occurs in the ___________ Prevents folding into ________ Leads to constitutive activation of _____ without _____ •Drives _______ cell proliferation.

Answer 28

JAK2 V617F MUTATION 2005 GUANINE-THYMINE; VALINE; PHENYLALANINE; CODON 617 JAK2 TYROSINE KINASE GENE INACTIVE STATE JAK2; ERYTHROPOIETIN (EPO)

Question 29

2 PHASES OF POLYCYTHEMIA VERA

Answer 29

PROLIFERATIVE (STABLE) PHASE (EARLY ACTIVE PHASE) SPENT PHASE ( LATE PHASE)

Question 30

WHICH PHASE OF POLYCYTHEMIA VERA IS THIS Increased ________ (hallmark of PV) •Overproduction of ____, ____, and ____ •Occurs ______of normal regulatory controls

Answer 30

PROLIFERATIVE (STABLE) PHASE RED CELL MASS RBCs, WBCs and PLATELETS INDEPENDENT

Question 31

WHICH PHASE OF POLYCYTHEMIA VERA IS CHARACTERIZED BY Progressive splenomegaly or hypersplenism Pancytopenia (reduction in all three blood cell lines) Bone marrow fibrosis (myelofibrosis) Ineffective hematopoiesis Morphologic shift toward postpolycythemic myeloid metaplasia

Answer 31

SPENT PHASE