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Pharm 1 > Chemo Drugs > Flashcards

Chemo Drugs Flashcards

1
Q

Types of Anti-cancer agents

A

cytotoxic agents

hormonal agents

biologicals

targeted drugs

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2
Q

Classes of cytotoxic agents

A 
Alkylating agents
Antimetabolites
Antitumor antibiotics
Mitotic inhibitors
Misc. cytotoxics
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3
Q

cytotoxic agents =

A

cell death

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4
Q

hormonal agents =

A

block effects of hormones on tumor

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5
Q

biologics=

Common A/E =

A

alter the body’s response to cancer

A/E = flu like symptoms

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6
Q

targeted drugs =

A

newer class, targets only cancer cells

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7
Q

drugs to deal with toxicities

A

Odansetron (Zofran) promethazine (Phenergan)
Dexamethasone
Magic mouthwash

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8
Q

MOa of cytotoxic agents

A

Disrupt DNA synthesis

Disrupt mitosis

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9
Q

Alkylating Agents

A

Cyclophosphamide

Cell cycle phase nonspecific

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10
Q

cyclophosphamide has usual toxcities plus….

A

Vesicant
Hemorrhagic cystitis
Sterility
Discoloration of skin and nails

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11
Q

Antimetabolite agent

A

methotrexate

cell cycle specific - S phase

Resemble natural metabolites

Folate antagonist

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12
Q

methotrrexate extra toxicites

A

Nephrotoxicity
Hepatotoxicity
Fetal death and abnormalities

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13
Q

Antitumor Antibiotics:

A

Doxorubicin (Adriamycin)

Cell cycle phase nonspecific

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14
Q

origin of doxorubicin

A

streptomyces

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15
Q

extra toxicites in doxorubicin

A

Cardiotoxicity(sometimes fatal)
Acute and delayed rxn

Can cause red urine and sweat

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16
Q

Mitotic Inhibitors: Vinca Alkaloids

A

Vincristine (Vincasar)

Cell cycle specific

17
Q

sources of vincristine

A

periwinkle- natural

18
Q

toxicities in vincristine

A

No bone marrow suppression in some drugs
Peripheral neuropathy
Vesicant

19
Q

Antiemetic: Serotonin Antagonist

A

Ondansetron (Zofran)

20
Q

uses of Ondansetron (Zofran)

A

chemo

radiation

postop

21
Q

moa Ondansetron (Zofran)

A

Blocks serotonin receptors on vagal nerve and in the CTZ
Chemoreceptor trigger zone
Efficacy is improved with steroids

22
Q

AE in ondansetron

A

HA
Diarrhea
dizzines

23
Q

Antiemetic:Dopamine Antagonist

A

Promethazine (Phenergan)

24
Q

uses of promethazine

A

Chemo, post-op, general N/V

25
Q

MOA of promethazine

A

Blocks dopamine receptors in the CTZ

26
Q

AE of promethazine

A

Respiratory depression
Drowsiness, sedation

Black box warnings = resp depression <2 yrs old; gangrenous extravasation

27
Q

MOA of biologics

A

uses body’s immune system to kill cancer cells

28
Q

Types of Biologics

A 
Immune checkpoint inhibitors
T-cell transfer therapy
Monoclonal antibodies
Treatment vaccines
Immune system modulators
29
Q

biologics approved in use for

A 
Leukemias/lymphomas
Breast
Bladder
Brain
Colon
Lung
Pancreatic
30
Q

SE of biologics

A 
Pain, Swelling, Soreness
Flu-like symptoms
Weight gain
Diarrhea
Risk of infection
31
Q

Routes of biologics

A

IV
Oral
Topical
Intravesical (directly into bladder)

Pharm 1 (28 decks)

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