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Pharm 1 > Pulmonary Anti-Inflammatories > Flashcards

Pulmonary Anti-Inflammatories Flashcards

1
Q

3 pulmonary anti-inflammatories

A

LTRAs

inhaled corticosteroids

mast cell stabilizers

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2
Q

2 Leukotriene receptor antagonist (LTRA) drugs

A

montelukast (Singulair)

zafirlukast (Accolade)

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3
Q

What do leukotrienes cause

A

inflammation, bronchoconstriction, and mucus production

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4
Q

MOA of leukotriene receptor antagonist (LTRA)

A

LTRAs prevent leukotrienes from attaching to receptors located on immune cells and within the lungs -> prevents inflammation

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5
Q

How is LTRAs given

A

PO

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6
Q

What are LTRAs used for

A

oral prophylaxis and chronic treatment of asthma in adults and children

Can also be given for allergies

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7
Q

What are LTRAs not used for

A

actue asthma attacks

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8
Q

Adverse effects of LTRAs

A 
headache
nausea
dizziness
insomnia
diarrhea
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9
Q

T/F Montelukast has few drug-drug interactions

A

TRUE

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10
Q

T/F Zafirlukast has several drug-drug interactions

A

TRUE

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11
Q

3 inhaled corticosteroids

A

beclomethasone diproprionate (Beclovent)

budesonide (Pulmicort Turbuhaler)

fluticasone (Flovent)

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12
Q

how are inhaled corticosteroids given

A

via nebulizer or MDI

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13
Q

MOA of inhaled corticosteroids

A

reduce inflammation and enhance activity of beta agonists

Also help with bronchodilation

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14
Q

how long will it take inhaled corticosteroids to be in full effect

A

several weeks

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15
Q

why is inhaled corticosteroids given

A

Given for prevention of persistent asthma attacks and long-term maintenance of severe COPD

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16
Q

T/F Inhaled corticosteroids are a rescue drug

A

FALSE

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17
Q

what needs to be taught for asthma with inhaled corticosteroids

A

teach to take on a regular schedule, not PRN & give the bronchodilator first to allow more thorough absorption of the steroids

18
Q

Adverse effects of inhaled corticosteroids

A

pharyngeal irritation, coughing, dry mouth, and oral fungal infections

19
Q

What should a patient do after inhaled corticosteroid use

A

rinse mouth

20
Q

What are the 2 combos of Inhaled glucocorticoid & bronchodilators

A

budesonide &formoterol (Symbicort)

fluticasone & salmeterol (Advair)

21
Q

what are inhaled glucocortiocoid and bronchodilator combos used for

A

Used for moderate to severe asthma

22
Q

key teaching point for glucocortiocoid and bronchodilator combos

A

NEVER USED FOR ACUTE ATTACKS

23
Q

Mast cell stabilizer drug

A

cromolyn (Intal)

24
Q

MOA of cromolyn

A

stabilize membranes of mast cells & prevent release of broncho-constrictive inflammatory substances

25
Q

what is cromolyn used for

A

prevention of acute asthma attacks

26
Q

when should cromolyn be administered

A

15-20 minutes prior to known triggers

27
Q

monoclonal antibody anti-asthmatic drug

A

omalizumab (Xolair)

28
Q

MOA of omalizumab

A

monoclonal antibody which selectively binds to immunoglobulin IgE -> limits the release of mediators of allergic response

29
Q

how is omalizumab be given

A

injection

30
Q

what must be monitored during omalizumab

A

Must be monitored closely for hypersensitivity reactions (anaphylaxis big risk)

31
Q

Indication of omalizumab

A

indicated for add-on therapy for asthma

32
Q

omalizumab is the newest generation of what

A

anti-asthmatic

33
Q

selective PDE-4 inhibitor drug

A

roflumilast

34
Q

MOA of roflumilast

A

selectively inhibits PDE4 enzyme in the lung cells

Potent anti-inflammatory effects within the lungs

35
Q

what is roflumilast indicated for

A

prevention of COPD exacerbations

36
Q

what is roflumilast not used for

A

acute/immediate action

37
Q

How is roflumilast

A

orally

38
Q

S/E for roflumilast

A

N/V/D,
headache,
muscle spasms, decreased appetite, uncontrollable tremors

39
Q

6 Long-term control medication PREVENTERS of asthma

A 
Anticholinergics
Xanthine derivative 
Inhaled corticosteroids
Leukotriene modifiers
Mast cell stabilizers
LABA
40
Q

2 quick relief medications of asthma

A

SABA

albuterol/Proventil

Pharm 1 (28 decks)

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