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Flashcards in Classic Labs/Findings Deck (112)
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1

inc AFP in amniotic fluid/maternal serum

dating error, anencephaly, spina bifida (neural tube defects)

2

Anti-centromere antibodies

Scleroderma (CREST)

3

Anti-desmoglein (anti-desmosome) antibodies

Pemphigus vulgaris (blistering)

4

Anti-glomerular basement membrane antibodies

Goodpasture syndrome (glomerulonephritis and hemoptysis)

5

Antihistone antibodies

Drug-induced lupus (eg hydralazine, isoniazid, phenytoin, procainamide)

6

Anti-IgG Antibodies

Rheumatoid arthritis (systemic inflammation, joint pannus, boutonniere defromity)

7

Antimitochondrial antibodies (AMAs)

Primary Biliary Cirrhosis (female, cholestasis, portal hypertension)

8

Antineutrophil cytoplasmic antibodies (ANCAs)

Microscopic polyangiitis and eosinophilic granulomatosis with polyangiits (Churg-Strauss sydnrome) (MPO-ANCA/p-ANCA); granulomatosis with polyangiitis (Wegener; PR3-ANCA/c-ANCA)

9

Antinuclear antibodies (ANAs: Anti-Smith and anti-dsDNA)

SLE (type III hypersensitivity)

10

Antiplatelet antibodies

Idiopathic thrombocytopenic purpura

11

Anti-topoisomerase antibodies

Diffuse systemic scleroderma

12

Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies

Celiac disease (diarrhea, weight loss)

13

"Apple core" lesion on barium enema x-ray

colorectal cancer (usually left-sided)

14

Atypical lymphocytes

EBV

15

Azurophilic peroxidase positive granular inclusions in granulocytes and myeloblasts

Auer rods (AML, especially the promyelocytic [M3] type)

16

Bacitracin response

Sensitivie: S pyogenes (group A); resistant: S agalactiae (group B)

17

"Bamboo spine" on x-ray

Ankylosing spondylitis (Chronic inflammatory arthritis; HLA-B27)

18

Basophilic nuclear remnants in RBCs

Howell-Jolly Bodies (due to splenectomy or nonfunctional spleen)

19

Basophilic stippling of RBCs

lead poisoning or sideroblastic anemia

20

bloody or yellow tap on lumbar puncture

subarachnoid hemorrhage

21

"boot shaped" heart on x-ray

Tetralogy of Fallot (due to RVH)

22

branching gram positive rods with sulfur granules

Actinomyces israelii

23

Bronchogenic apical lung tumor on imaging

Pancoast tumor (can compress cervical sympathetic chain and cause Horner syndrome)

24

"Brown" tumor of bone

Hyperparathyroidism or osteitis fibrosa cystica (deposited hemosiderin from hemorrhage gives brown color)

25

Cardiomegaly with apical atrophy

Chagas disease (Trypanosoma cruzi)

26

Cellular cresents in Bowman capsule

Rapidly progressive crescentic glomerularnephritis

27

"chocolate cyst" of ovary

endometriosis (frequently involves both ovaries)

28

Circular grouping of dark tumor cells surrounding pale neurofibrils

Homer-Wright Rosettes (neuroblastoma, medulloblastoma)

29

Colonies of mucoid Pseudomonas in lungs

Cystic fibrosis (autosomal recessive mutation in CFTR gene ---> fat soluble vitamin deficiency and mucous plugs)

30

dec AFP in amniotic fluid/maternal serum

Down syndrome or other chromosomal abnormalities