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Flashcards in Mnemonics Galore! Deck (187)
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1

SNNOUT

sensitivity
highly SeNsitive test, when Negative, rules OUT dz

2

SPPIN

highly SPecific test, when Positive, rules IN dz

3

type I (alpha) error

you sAw a difference that didn't exist (eg, convicting an innocent man)

4

type II (beta) error

you were Blind to the truth (eg, setting a guilty man free)

5

PST

disease prevention
primary: prevent
secondary: screen
tertiary: tx

6

4 parts of Medicare

Part A: hospitAl insurance
Part B: Basic medical Bills (eg, doctor's fees, dxic testing)
Part C: (Parts A+B) delivered by approved private Companies
Part D: prescription Drugs

7

Sex, Drugs, & Rock & roll

situations in which parental consent usually not required for minors
Sex (contraception, STIs, pregnancy)
Drugs (addiction, tx for child of minor)
Rock & roll (emergency/trauma)
*abortion does require at minimum parental notification in most states*

8

GAG

amino acids necessary for purine synthesis
Glycine, Aspartate, Glutamine

9

HGPRT

sx of Lesch-Nyhan syndrome (defective HGPRT)
Hyperuricemia ("orange sand" in diaper), Gout, Pissed off (aggression, self-mutilation), Retardation (intellectual disability), dysTonia

10

eukaryotic DNA polymerases

Alpha - lAgging strand
Beta - Base excision repair
Delta - leaDing strand
GaMMa - Mitochondrial DNA (or gamma for "Gramma")

11

APE

positions of active sites on ribosome
A site - incoming Aminoacyl-tRNA
P site - accommodates growing Peptide
E site - holds Empty tRNA as it Exits

12

Microtubules Get Constructed Very Poorly

drugs that act on microtubules
Mebendazole (antihelminthic)
Griseofulvin (antifungal)
Colchicine (antigout)
Vincristine/Vinblastine (anticancer) - destabilize/inhibit MT formation
Paclitaxel (anticancer) - hyperstabilizes MTs

13

SCAB or Be (So Totally) Cool, Read Books

types of collagen
Type I: Bone, Skin, Tendon, dentin, fascia, cornea, late wound repair
Type II: Cartilage (including hyaline), vitreous body, nucleus pulposus
Type III: Reticulin - skin, blood vessels uterus, fetal tissue, granulation tissue
Type IV: Basement membrane, basal lamina, lens

14

SNoW DRoP or Down South, Pools in the West, and Rhode Island to the North

different blotting procedures
Southern blot: DNA sample, DNA probe
Western blot: protein sample, labeled antibody probe
Northern blot: RNA sample, DNA probe
Southwestern blot: DNA-binding protein sample (eg, transcription factor), labeled oligonucleotide probe

15

Cs of Huntington disease

trinucleotide repeat: CAG
Cuatro (chromosome 4)
Cuarenta (median age of onset)
Choreiform movements
Caudate atrophy
Cognitive decline
decreased ACh in brain

16

Oblivious Female Will Give Her Boys Her x-Linked Disorders...Oops

X-linked disorders! (duh)
Ocular albinism, Fabry dz, Wiskott-Aldrich syndrome, G6PD deficiency, Hemophilia A and B, Bruton agammaglobulinemia, Hunter syndrome, Lesch-Nyhan syndrome, Duchenne (and Becker) muscular Dystrophy, Ornithine transcarbamylase deficiency

17

X-Girlfriend's First Aid Helped Ace My Test

trinucleotide repeat conditions and which mutations
Fragile X syndrome: (CGG)n
Friedreich ataxia: (GAA)n
Huntington dz: (CAG)n
Myotonic dystrophy: (CTG)n

18

CATCH-22

DiGeorge syndrome!
microdeletion at chromosome 22q11
Cleft palate
Abnormal facies
Thymic aplasia -> T cell deficiency
Cardiac defects
Hypocalcemia (d/t parathyroid aplasia)

19

FLAMES

findings of kwashiorkor
Fatty Liver
Anemia/Anasarca
Malnutrition
Edema
Skin lesions

20

HUGs take two

biosynthetic processes that take place in both cytoplasm and mitochondria
Heme synthesis, Urea cycle, Gluconeogenesis

21

Citrate Is Krebs' Starting Substrate For Making Oxaloacetate

order of substrates in TCA cycle
Citrate
Isocitrate
alpha-Ketoglutarate
Succinyl-CoA
Succinate
Fumarate
Malate
Oxaloacetate

22

Spleen Purges Nasty Inclusions From Damaged Cells

substances that induce hemolysis in G6PD deficiency
Sulfonamides
Primaquine
Nitrofurantoin
Isoniazid
Fava beans
Dapsone
Chloroquine

23

PriVaTe TIM HaLL

essential amino acids
Phenylalanine
Valine
Tryptophan
Threonine
Isoleucine
Methionine
Histidine
Lysine
Leucine

24

Ordinarily, Careless Crappers Are Also Frivolous About Urination

order of substrates in urea cycle
Ornithine
Carbamoyl phosphate
Citrulline
Aspartate
Argininosuccinate
Fumarate
Arginine
Urea

25

I Love Vermont maple syrup from maple trees w/ branches

maple syrup urine dz
blocked degradation of branched chain aas (Isoleucine, Leucine, Valine) d/t decreased alpha-ketoacid dehydrogenase

26

Even Some Pretty Nasty Killers Have Shiny Bodies

encapsulated organisms
E. coli (some)
Streptococcus pneumoniae
Pseudomonas aeruginosa
Neisseria meningitidis
Klebsiella pneumoniae
Haemophilus influenzae B
Salmonella
Group B strep species

27

These Microbes May Lack Real Color

bugs that don't Gram stain well
Treponema pallidum (too thin)
Mycobacteria (mycolic acids)
Mycoplasma (no cell wall)
Legionella pneumophila (primarily intracellular)
Rickettsia (intracellular parasite)
Chlamydia (intracellular parasite; low muramic acid)

28

ENDOTOXIN

effects of endotoxin (LPS, G- bacteria)
Edema
Nitric oxide
DIC/Death
Outer membrane
TNF-alpha
O-antigen
eXtremely heat stable
IL-1
Neutrophil chemotaxis

29

ABCDE bacterial toxins

bacterial toxins encoded in lysogenic phage
shigA-like toxin
Botulinum toxin (certain strains)
Cholera toxin
Diphtheria toxin
Erythrogenic toxin of S. pyogenes

30

MOPS

Strep pneumo is MCC of:
Meningitis
Otitis media (in children)
Pneumonia
Sinusitis