Connective Tissue

Question 1

found in basement membrane; aids in adhesion between cell membrane and extracellular matrix via interaction of adhesion molecules called integrins

Answer 1

fibronectin

Question 2

organic extracellular matrix made up of various fibers; amorphous, transparent material with properties of a semi-fluid fel; long, unbranched polysaccharide chains of repeating disaccharide units; one of the two sugars in always an amino sugar

Answer 2

ground substance

Question 3

fibers that make up ground substance

Answer 3

elastin, reticulin, and collagen

Question 4

collagen containing thin branching net-like fibers (reticulin fibers); for structural support in organs; argyrophilic

Answer 4

type 3 collagen

Question 5

includes blood, bone, cartilage, adipose tissue, hematopoietic tissue, lymphatic tissue, mesenchymal and mucus connective tissue

Answer 5

specialized connective tissue

Question 6

autosomal dominant condition resulting in abnormal elastic fibers; characterized by tall stature, long limbs, and long thin fingers; enlarged aorta with increased regurgitation and increased risk of developing a dissecting aneurysm

Answer 6

Marfan’s syndrome

Question 7

makes up 90% of the collagen in the body and makes up loose & dense connective tissue of skin, tendons, ligaments, bone & fibrocartilage

Answer 7

type 1 collagen

Question 8

provides structural support and metabolic support for other tissues and organs; carries blood vessels and functions in tissue repairs; mediates exchange of nutrients/metabolites/waste products between tissue and circulation

Answer 8

connective tissue

Question 9

collagen fibers oriented parallel to each other; densely packed fibers and cells arranged in fascicles

Answer 9

regular dense connective tissue

Question 10

fibroblasts with contractile ability used in wound contraction

Answer 10

myofibroblasts

Question 11

collagen found in basement membrane that forms an open meshwork

Answer 11

type 4 collagen

Question 12

multilocular fat that is highly specialized; present in infants and hibernating animals; used in thermoregulation to maintain body temperature, located in adrenals of humans; large #’s of mitochondria that produce heat

Answer 12

brown fat

Question 13

highly branched; random coiling pattern allows stretching; arranged in fibers and sheets; refractile; synthesized by fibroblasts as tropoelastin precursor

Answer 13

elastic fibers

Question 14

don’t compact well; negatively charged due to sulfate and carboxyl side groups that are hydrophilic that forms gel; make up most of ground substance; reinforced with fibrous proteins

Answer 14

glycosaminoglycans

Question 15

responsible for storage and metabolism of lipids; large, balloon-shaped, clear spaces filled with lipid

Answer 15

adipocytes

Question 16

sparse fibers and abundant ground substance; supportive function; located beneath epithelia and around nerves and vessels

Answer 16

loose (areolar) connective tissue

Question 17

best known collagenopathy that affects type 5 collagen; characterized by hyperextension of joints, skin fragility, and poor wound healing

Answer 17

Ehlers-Danlos Syndrome

Question 18

pointed, elongate, spindle shaped cells that synthesize and maintain proteinaceous ground substance and connective tissue fibers

Answer 18

fibroblasts

Question 19

protein core similar to collagen, surrounded by microfibrils of fibrillin

Answer 19

elastin

Question 20

collagen synthesis

Answer 20

procollagen secreted into ECS to tropocollagen to collagen microfibrils to collagen bundle

Question 21

cells morphologically similar to primitive mesenchymal cells that look like branched fibroblasts; have phagocytic function

Answer 21

reticular cells

Question 22

non filamentous molecules associated with basement membrane

Answer 22

laminin, entactin, and tenascin

Question 23

contains adipocytes; functions in energy storage, thermoregulation and as shock absorber

Answer 23

adipose tissue

Question 24

collagen fibers oriented randomly; moderate number of fibers and few cells

Answer 24

irregular dense connective tissue

Question 25

predominant GAG in loose connective tissue; lacks sulfonated groups, several thousand sugars long, does not form proteoglycans itself but can bind with them

Answer 25

hyaluronic acid

Question 26

glycoprotein that precursor proteins produced by fibroblasts; has at least 28 different types, principle fiber in extracellular matrix and provides tensile strength

Answer 26

collagen

Question 27

unilocular fat distributed in dermis and around intraperitoneal organs

Answer 27

white fat

Question 28

collagen found in hyaline and elastic cartilage

Answer 28

type 2 collagen

Question 29

provides structural support- abundant fibers, moderate number of cells, lesser ground substance

Answer 29

dense connective tissue