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Flashcards in Connective Tissue Disease Deck (20):
1

TRUE or False
People with high oestrogen levels are more likely to suffer from Systemic Lupus Erythematosus?

TRUE

2

What virus has an association with Systemic Lupus Erythematosus?

Epstein-Barr Virus

3

What may UV light stimulate in SLE?

skin cells to secrete cytokines stimulating B cells

4

What do necrotic cells release in SLE?

nuclear material which act as potential autoantigens.

5

What do the autoantigens stimulate?

B and T cells
autoantibodies

6

What symptoms accompany SLE?

Fever
Malaise
Poor appetite
Weight loss
Fatigue

7

What mucocutaneous features appear in SLE?

photosensitivity
malar rash
discoid lupus erythmatosus
subacute cutaneous lupus

8

What musculoskeletal features are involved in SLE?

polyarthtitis/polyarthralgia
deforming arthropathy
Jaccoud's arthritis
erosive arthritis
myopathy, myalgia and myositis

9

What pulmonary features are associated with SLE?

Pleurisy
Infections
Diffuse lung infiltration and fibrosis
Pulmonary hypertension
Pulmonary infarct

10

What cardiac problems are associated with SLE?

Pericarditis
Cardiomyopathy
Pulmonary hypertension
Libman-Sachs endocarditis

11

How would glomeruloephritis present itself?

Proteinuria
Urine sediments
Urine RBC and casts
Hypertension
Acute renal failure
Chronic renal failure

12

What neurological features are associated with SLE?

Depression/psychosis
Migranous headache
Cerebral ischaemia
Cranial or peripheral neuropathy
Cerebellar ataxia

13

What haematological features of SLE are there?

Lymphodenopathy
Leucopenia
Anaemia
Thromboctopenia

14

What investigations should be done for SLE?

FBC
Renal function tests including urine examination
Anti-nuclear antibody
Anti-double stranded DNA antibodies
ENA
Complement levels

15

What is a positive anti-nuclear antibody test?

Titre of 1:160

16

What is the general management of Lupus?

Counselling
Monitoring
Avoid sun exposure
Pregnancy issues

17

What are the drugs used in SLE treatment?

NSAID's and analgesia
Anti-malarias - hydroxychloroquine

18

Can steroids be used in SLE?

yes, but side-effects must be taken into account

19

Can immunosuppressives be used in SLE?

Yes

20

What biologics can be used in SLE?

Anti-CD20 - Rituximab
Anti-Blys - Belimumab