Vasculitis Flashcards Preview

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Flashcards in Vasculitis Deck (25):
1

What is vasculitis?

Inflammation of the blood vessels, with ischaemia, necrosis and organ inflammation

2

What systemic symptoms are associated with vasculitis ?

Fever
malaise
Weight loss
Fatigue

3

What are the two main types of large vessel vasculitis?

Takayasu arthritis (TA)
Giant Cell arthritis (GCA)

4

What age group mainly get TA and GCA?

TA = under 40's
GCA = over 50's

5

Which of either GCA or TA have granulomatous infiltration of the walls of the large vessels ?

Both of them

6

What findings would be present in large vessel vasculitis?

Bruit
Blood pressure difference of extremities
Claudication
Carotodynia or vessel tenderness
Hypertension

7

What disease has a high association with GCA?

Polymyalgia rheumatica

8

What are classic symptoms of Temporal arthritis?

Unilateral temporal headache
scalp tenderness
jaw claudication

9

What causes the possibility of blindness in temporal arthritis?

ischaemia of the optic nerve

10

What investigations are there for temporal arhtritis?

ESR plasma viscosity CRP are all raised
MR angiogram
PET CT scan

11

What is the management for Temporal arthritis?

40-60mg starting dose of prednisolone
Methotrexate or azothiaprine may be used

12

Give 2 examples of medium vessel vasculitis?

kawasaki disease - under 5's
Polyartheritis, resulting in microaneurysm formation

13

What virus does medium vessel vasculitis have an association with?

Hepatitis B

14

What are some ENT features of vasculitis?

Sinusitis
Nasal crusting
Epistaxis
Mouth ulcers
Sensorineural deafness
Otitis media and deafness
Saddle nose - due to cartilage ischaemia

15

What respiratory problems may accompany vasculitis?

Pulmonary infiltrates
Cough
Hemoptysis
Diffuse alveolar hemorrhage
cavitating nodules on CXR

16

What cutaneous problems may occur in vasculitis?

palpable purpura
Cutaneous ulcers

17

What renal problems may occur in vasculitis?

Necrotising glomerulonephritis
Manifests as blood and protein in urine

18

What nervous system problems may occur in vasculitis?

Mononeuritis multiplex
Sensorimotor polyneuropathy
Cranial nerve palsies

19

What ocular problems may occur in vasculitis?

Conjunctivitis
Episcleritis
Uveitis
optic nerve vasculitis
retinal artery occlusion
proptosis

20

What occurs in Eosinophilic granulomatosis with Polyangiitis?

late onset asthma and high eosinophil count

21

What is Henoch-Schonlein Purpura? (HSP)

An acute immunoglobulin A (IgA) mediated disorder

22

When do most HSP cases occur?

between the ages of 2-11 years

23

Infection of what organism often accompanies HSP?

Group A Strep (usually occurs up to 3 weeks before HSP)

24

How does HSP present?

Purpuric rash typically over buttocks and lower limbs
Colicky abdo pain
Bloody diarrhoea
joint pain/swelling
Renal involvement (50%)

25

How do you manage HSP?

Tends to resolvewithin 8 weeks
May relapse
Must perfrom urinalysis to screen for renal problems