Flashcards in Vasculitis Deck (25):
What is vasculitis?
Inflammation of the blood vessels, with ischaemia, necrosis and organ inflammation
What systemic symptoms are associated with vasculitis ?
What are the two main types of large vessel vasculitis?
Takayasu arthritis (TA)
Giant Cell arthritis (GCA)
What age group mainly get TA and GCA?
TA = under 40's
GCA = over 50's
Which of either GCA or TA have granulomatous infiltration of the walls of the large vessels ?
Both of them
What findings would be present in large vessel vasculitis?
Blood pressure difference of extremities
Carotodynia or vessel tenderness
What disease has a high association with GCA?
What are classic symptoms of Temporal arthritis?
Unilateral temporal headache
What causes the possibility of blindness in temporal arthritis?
ischaemia of the optic nerve
What investigations are there for temporal arhtritis?
ESR plasma viscosity CRP are all raised
PET CT scan
What is the management for Temporal arthritis?
40-60mg starting dose of prednisolone
Methotrexate or azothiaprine may be used
Give 2 examples of medium vessel vasculitis?
kawasaki disease - under 5's
Polyartheritis, resulting in microaneurysm formation
What virus does medium vessel vasculitis have an association with?
What are some ENT features of vasculitis?
Otitis media and deafness
Saddle nose - due to cartilage ischaemia
What respiratory problems may accompany vasculitis?
Diffuse alveolar hemorrhage
cavitating nodules on CXR
What cutaneous problems may occur in vasculitis?
What renal problems may occur in vasculitis?
Manifests as blood and protein in urine
What nervous system problems may occur in vasculitis?
Cranial nerve palsies
What ocular problems may occur in vasculitis?
optic nerve vasculitis
retinal artery occlusion
What occurs in Eosinophilic granulomatosis with Polyangiitis?
late onset asthma and high eosinophil count
What is Henoch-Schonlein Purpura? (HSP)
An acute immunoglobulin A (IgA) mediated disorder
When do most HSP cases occur?
between the ages of 2-11 years
Infection of what organism often accompanies HSP?
Group A Strep (usually occurs up to 3 weeks before HSP)
How does HSP present?
Purpuric rash typically over buttocks and lower limbs
Colicky abdo pain
Renal involvement (50%)