Flashcards in Tumour pathology Deck (20):
What is Osteochondroma (Exostosis)
Cartilage capped bony projections arising on external surface of bone containing a marrow cavity that is continuous with that of the underlying bone
Where is Osteochondroma more likely to occur?
The young, and in epiphyses of long bones, origin is chondrocyte
What is a chondroma (enchondroma)
Benign hyaline cartilage tumour arising in medullary cavity of bones of hands and feet
Where is chondroma more likely to occur?
More likely in men, in young adults, can be single or multiple
Explain Ollier's disease
Echondromas (metaphyses and diaphyses),
typically unilateral, one extremity. not familial.
malignancy = 10-25%
What is Maffucci's Syndrome?
Multiple enchondromatosis with soft tissue and visceral haemangiomas
What has a higher chance of malignancy, Maffucci's or Ollier's?
What is Osteoid Osteoma?
Benign lesion in kids and young adults, more males than woman and found in femur, tibia, hands/feet, axial skeleton
Where are Osteoid osteoma's found?
Central core of vascular osteoid
peripheral zone of sclerotic bone
What clinical features of Osteoid osteoma are there?
Dull pain, worse at night, relieved by aspirin/NSAIDs
What is Chondroblastoma?
Benign cartilage tumour arising in bone
Where are chondroblastoma found?
Epiphysis of long bones
Describe features of Giant Cell Tumour?
Origin is at the Osteoclast,
age group is 25-40 years,
more woman than men
5-9% of bone primary tumours
long bones, often around the knee
What does the histology of osteoblastoma show?
Irregular spicules of mineralised bone and osteoid surrounded by osteoblasts
Vascular stroma with pleomorphic spindle cells
Osteoid and woven bone are seen
What is Chordoma?
Tumour arising from notocord remnants (often in sacral region)
Older adults +40, more in females, benign but destructive and invasive
What is Osteosarcoma?
Malignant osteoblasts forming osteoid
Chondrosarcoma exhibits differentiation of what?
What is chondrosarcoma composed of?
What is PNET?
Peripheral primitive neuroectodermal tumour