Cytokine producing Cells of IBD

Question 1

these immune cells live in the GI tract interact with T cells in mesenteric lymph nodes to cause differentiation of naive T lymphs into Tregs in response to microbial antigens (tolerance).

Answer 1

Local dendritic cells (CD103+ CD11b+)

Question 2

these cells produce TGF-beta to inhibit action of other T cells.
(dampens the immune response) and also IL-10

Answer 2

Tregs

Question 3

IL-10 is produced by these cells and acts to inhibit MHC class II and costimulatory B7 expression to decrease pro-inflammatory cytokine production.

Answer 3

DCs and Th2 cells

Question 4

HLADQ2 or DQ8 is linked to what disease?

Answer 4

Celiac disease

Question 5

This type of helper T cells releases these cytokines?

Answer 5

Th1

IFN-gamma and TNF-alpha

Question 6

Cytotoxic targets

MHC I

EC death

what is this cytokine?

Answer 6

IFN-gamma

Question 7

Apoptosis

what is this cytokine?

Answer 7

TNF-alpha

Question 8

what are the inflammatory cells involved in IBD?

Answer 8

macrophages and T cells (helper T cells and Th 17), ILCs

Question 9

what are the cytokines produced by APC derived cytokines in IBD?

Answer 9

IL-1b,6, 12,18, 23 and TNFalpha

Question 10

what are the cytokines produced by ILCs in IBD?

Answer 10

IFN-g, IL-17, IL-22

Question 11

what are the cytokines produced by Th1 in IBD?

Answer 11

IFN-g

Question 12

what are the cytokines produced by Th2 in IBD?

Answer 12

IL-5,IL-13

Question 13

what are the cytokines produced by Th17 in IBD?

Answer 13

IL-17, IL-22

Question 14

this cytokine of IBD also increases the risk of cancer?

Answer 14

IL-22

Question 15

defective NOD2 signaling is indicated in this disease and causes Th1/Th17 to produce these cytokines?

what pathway in activated by NOD2 signaling?

Answer 15

Crohns

IL-1, 6, 12, 17, TNFa, IFNg) inflammation (“gain of function mutation”)

NF-KB

Question 16

what cytokines are indicated in the management of IBD?

Answer 16

anti-TNF
anti IL-12
anti IL-23