lecture 36 terms

Question 1

structural that binds keratin in the skin to epithelial cells and promotes nice strong barrier against pathogens

Answer 1

filaggrin

Question 2

red, patchy, raised skin rash

Answer 2

papules

Question 3

dry rectangular scales on skin of lower legs and shins (fish scale-like)

Answer 3

Ichthyosis

Question 4

small rough bumps on face, arms, thighs (gooseflesh skin)

Answer 4

Keratosis pilaris

Question 5

inflammation of skin on and around lips

Answer 5

Hyperlinear palms and cheilitis

Question 6

Dennie Morgan line; extra fold of skin under the eye? and very indicative of this disease?

Answer 6

Atopic pleat

atopic dematitis

Question 7

Blisters ooze & crust, may get infected.

Chronic atopic dermatitis can lead to tough/thickened skin

Answer 7

lichenification

Question 8

general term for a group of rare autoimmune blistering epithelial disorders that results from loss of normal intercellular attachments in epidermis

Answer 8

Pemphigus

Question 9

autoimmune destruction of desmoglein 1 (in epidermis, esp scalp). Least severe form of pemphigus

Answer 9

Pemphigus foliaceus

Question 10

autoimmune destruction of desmoglein 3 lesions in epidermis & mucous membranes (e.g., in mouth) (basal layer of epidermis- 2ndary bacterial infections)

Answer 10

Pemphigus vulgaris (more severe)

Question 11

firm sliding pressure with finger separates normal-appearing epidermis, producing an erosion

Answer 11

Positive Nikolsky’s sign

Question 12

Punch biopsy, histopath: intraepithelial blister, intercellular edema and loss of cell attachments

Answer 12

acantholytic cells

Question 13

The basal layer of keratinocytes are usually still hanging onto the basement membrane

Answer 13

tombstoning

Question 14

showing antibody deposits and activation of complement, and ELISA for IgG4, IgG1, C’

Answer 14

Direct immunofluorescent staining

Question 15

rounded, nucleated keratinocytes formed due to antibody-mediated damage of desmoglein

Answer 15

Tzanck smear

Question 16

Sulfasalazine, pentoxifylline are what type of drugs?

Answer 16

anti TNF drugs

Question 17

Rituximab is comprised of?

Answer 17

anti-CD20 antibody + IVIG

Question 18

mycophenolate mofetil, azathioprine are a type of?

Answer 18

immunosuppressants

Question 19

present in >90% of scleroderma patients

Vasospasm that causes discoloration of fingers and toes.

Makes digits turn blue, cold, and numb (like frostbite)

Answer 19

Raynaud’s phenomenon

Question 20

skin lesions on lines of trauma (like poison ivy)

Answer 20

Koebner phenomenon

Question 21

usually asymmetric peripheral joint involvement, less commonly symmetric joint or axial disease

Answer 21

psoriatic arthritis

Question 22

Condition in which lighter patches develop on the skin due to loss of melanin pigmentation

Melanocyte destruction.

Any location on the body may be affected.

Answer 22

Vitiligo

Question 23

one or few areas of depigmentation

Answer 23

Focal pattern

Question 24

depigmentation on one side of the body

Answer 24

Segmental pattern

Question 25

depigmentation symmetrically – *most common*

Answer 25

Generalized pattern