Evasion of Cytolysis----------------------------- Flashcards
Check on Learning (3 cards)
1
Q
these viruses encode a molecule which mimics the ligand bound by NK cell inhibitory proteins
A
CMV, HepC, HIV, KIR, Ly49
2
Q
other viruses that encode proteins which inactivate the death protease which is a complex of caspases and adaptor proteins and these viral proteins are called vFLIPs
A
HHV8 and EBV
3
Q
how can cytolysis be inhibited?
A
down regulation of costimulatory and adhesion molecules (prevents immuno synapse)
down regulating the death receptors (TNF-R, NKG2D)
upregulating supressor molecules (PD1, IL-10)
