lecture 34-35 terms

Question 1

may alter self tolerance mechanisms

Answer 1

genetic susceptibility

Question 2

a chronic multi systemic inflammatory autoimmune disease

Answer 2

lupus

Question 3

an environmental susceptibility in which there is tissue damage causing increased self-Ags

Answer 3

UV light

Question 4

an environmental susceptibility in which there are viral infections causing molecular mimicry

Answer 4

microbial

Question 5

an environmental susceptibility in which there is tissue damage or molecular mimicry

Answer 5

drug exposure

Question 6

many antibodies made in lupus?

Answer 6

extractable nuclear antigens (ENAs)

Question 7

the ENA thats the best screening test for lupus?

Answer 7

anti-nuclear Ab (ANA)

Question 8

the ENA thats more specific than ANA for lupus?

Answer 8

anti-double stranded DNA Ab

Question 9

the ENA that is very specific for lupus, especially in chronic lupus?

Answer 9

anti-smith, especially for chronic lupus

Question 10

in lupus pathogenesis, this is very evident:

DNA extrusion + pathogen trapping, + cell death

Answer 10

NETosis

Question 11

erythematous plaques with central scarring

Answer 11

Discoid skin lesions

Question 12

reduced blood flow to extremities – cold, discolored digits

Answer 12

Raynaud’s phenomenon

Question 13

musculoskeletal manifestation that is the most common presenting feature of SLE
Symmetric, somewhat inflammatory, involves PIP and MCP joints

Answer 13

Arthralgia/non-erosive arthritis

Question 14

musculoskeletal manifestation that is seen in the hip and shoulder joints
Related to previous arthritis, or treatment with steroids or cytotoxic drugs

Answer 14

Osteonecrosis

Question 15

musculoskeletal manifestation that has Mild inflammation: proximal muscle weakness
Rare and often associated with steroid treatment.
Clinically you see an increase in serum creatine kinase (CK) activity

Answer 15

myositis

Question 16

what is are the two criteria for SLE?

Answer 16

clinical (skin, vascular, blood) and immunologic criteria (immunologic)

Question 17

calcium deposits in the skin

Answer 17

calcinosis

Question 18

spasm of blood vessels in response to cold or stress

Answer 18

raynauds phenomenon

Question 19

acid reflux and decrease in motility of esophagus

Answer 19

esophageal dysfunction

Question 20

thickening and tightening of the skin on fingers and hands

Answer 20

sclerodactyly

Question 21

dilation of capillaries causing red marks on surface of skin

Answer 21

telangectasias

Question 22

dry eye

Answer 22

keratoconjunctivitis sicca

Question 23

dry mouth, dry cracked tongue, dry sore throat

Answer 23

Xerostomia

Question 24

synovitis/doughy swelling, worst in morning, swelling subsides with movement

Answer 24

rheumatoid arthritis

Question 25

erosion of cartilage causing bones to rub together (wear and tear), pain gets worse with movement

Answer 25

osteoarthritis

Question 26

hyperflexed PIP, hyperextended DIP

Answer 26

Boutonniere deformity

Question 27

hyperextended PIP, hyperflexed DIP

Answer 27

Swan neck deformity

Question 28

type of stiffness that lasts generally > 1 hr

Answer 28

Morning stiffness

Question 29

vasculitis with necrosis and granulomatous inflammation

Answer 29

Chronic inflammation

Question 30

disease modifying anti-rheumatic drugs. These include biologics and non-biologics Immunosuppressive agents can decrease the body’s ability to fight diseases – so VACCINATE your patients and screen for tuberculosis

Answer 30

DMARDS

Question 31

spine completely fuses

Answer 31

bamboo spine

Question 32

the site of attachment of a muscle or ligament to bone

Answer 32

Enthesis

Question 33

inflammation where tendon meets bone

Answer 33

Enthesitis

Question 34

inflammation of a digit

Answer 34

Dactylitis

Question 35

inflammation and swelling of a tendon sheath

Answer 35

Tenosynovitis

Question 36

affecting 2-4 joints (1 joint = monoarticular, >4 = polyarticular)

Answer 36

Oligoarthritis

Question 37

not the same joints on the opposites sides of the body

Answer 37

Asymmetric

Question 38

inflammation of the joints of the backbone

Answer 38

Spondylitis

Question 39

ESR

Answer 39

erythrocyte sedimentation rate

Question 40

CRP

Answer 40

c – reactive protein

Question 41

CASPAR

Answer 41

Classification of Psoriatric Arthritis Study Group

Question 42

methotrexate, cyclosporine, sulfasalazine, leflunomide

Answer 42

DMARDs

Question 43

etanercept, infliximab, adalimumab (Humira)

Answer 43

Biologics