Important Inflammatory Cytokines Flashcards
check on learning (15 cards)
Augments recruitment of granulocytes, stimulates IL-6 production.
IL-1beta
Acute phase response by liver, activates macrophages and T cells.
IL-6
Increases IL-17 production by Th-17s, activates ILCs, suppresses Tregs.
IL-12
Augments production of pro-inflammatory cytokines.
IL-18
Activates T cells, Th17 cells, & macrophages; augments TNF production.
IL-23
Augments angiogenesis, increases MMP by myofibroblasts
kills Paneth cells, activates macrophages, T cells, and fibroblasts.
TNFalpha
anti-inflammatory DCs, promote Treg differentiation and anti-inflammatory cytokine production
CD103+ CD11b+
subset of DCs that migrate into the intestine from the blood when the gut becomes irritated, are more immunogenic.
CD103-CD11b+
activates macrophages and APCs
IFN-g
induces inflammation and fibrosis
IL-17
activates epithelial cell proliferation and favors tumor development
This cytokine typically helps to heal damaged epithelium to restore the barrier.
But it can lead to uncontrolled proliferation of epithelial cells causing GI cancer.
IL-22
activates macrophages and APCs
IFN-g
activate NKT cells, enhance fibrosis, disrupt epithelial barriers
IL-5, IL-13
induce inflammation, chemotaxis, and fibrosis
IL-17, IL-22
anti-inflammatory cytokines
IL-10, TGF-beta
