Day 7

Question 1

overall three dimensional arrangement of all th atoms in a protein

Answer 1

tertiary structure

Question 2

what holds segments in position in tertiary structure

Answer 2

weak interactions and covalent bonds

Question 3

arrangement of 2+ separate polypeptide chains in 3D complexes

Answer 3

quaternary structure

Question 4

how many major types of proteins based on polypeptide chains

Answer 4

4a

Question 5

arranged in long strands or sheets

Answer 5

fibrous proteins

Question 6

folded into a spherical or globular shape

Answer 6

globular proteins

Question 7

embedded in a hydrophobic lipid membranea

Answer 7

membrane proteins

Question 8

lacking stable tertiary strucurres

Answer 8

intrinsically disordered proteins

Question 9

givers strength and or flexibility to structure s

Answer 9

fibrous proteins

Question 10

simple repeating element of secondary structure

Answer 10

fibrous proteins

Question 11

example of right handed alpha helix

Answer 11

alpha kertatin

Question 12

main protein in silk

Answer 12

fibroin

Question 13

predominately beta sheets conformation

Answer 13

fibroin

Question 14

what is fibroin rich n

Answer 14

alanine and glycine

Question 15

what is fibroin stabilized by

Answer 15

hydrogen bonding and van der waals interactions

Question 16

found in connective tissue

Answer 16

collagen

Question 17

what is the secondary structure of collagen

Answer 17

left handed helix

Question 18

what is tertiary and quaternary structure of collagen

Answer 18

right handed twisting of 3 separate polypeptides

Question 19

what is caused by lack of vitamin C

Answer 19

scurvy

Question 20

fold back on each other, more compact than fibrous proteins

Answer 20

globular proteins

Question 21

enzymes, transport proteins, motor proteins, regulatory proteins, immunoglobins are all what

Answer 21

globular proteins

Question 22

lack definable structure

Answer 22

instrinsically disordered proteins

Question 23

often lack a hydrophobic core

Answer 23

intrinsically disordered proteins

Question 24

high densities of charged residues and proline

Answer 24

intrinsically disordered proteins

Question 25

motif = what

Answer 25

fold

Question 26

recognizable folding pattern involving 2+ elements of secondary structure and the connections

Answer 26

motif/fold

Question 27

assembly of multiple peptide subunits, what structure

Answer 27

quaternary structure

Question 28

repeating structural unit

Answer 28

protomer

Question 29

multisubunit protein

Answer 29

oligomer/multimer

Question 30

loss of 3D structure sufficient to cause loss of function

Answer 30

denaturation

Question 31

what can cause denaturation

Answer 31

heat, pH extremes, miscible solvents, certain solutes, detergents

Question 32

what does denaturation often lead to

Answer 32

protein precipitation

Question 33

process by which certain denatured globular proteins regain their native structure and biological activity

Answer 33

renaturation

Question 34

can all proteins undergo renaturation

Answer 34

no

Question 35

2 kinds of protein folding

Answer 35

spontaneous and assisted folding

Question 36

based on amino acid r group interactions, what folding type

Answer 36

spontaneousg

Question 37

guided by chaperone proteins

Answer 37

assisted folding

Question 38

binds to hydrophobic regions

Answer 38

HSP 70

Question 39

protein complexes assign in protein folding

Answer 39

chaperonins

Question 40

misfolded protein

Answer 40

prion

Question 41

what dictates protein function

Answer 41

structure of the protein

Question 42

many proteins require what to function

Answer 42

binding to a ligand

Question 43

anything that binds the protein at a specific site

Answer 43

ligand

Question 44

protein functions can either be grouped as what or what

Answer 44

catalytic or noncatalytic

Question 45

example of non catalytic protein functiosn

Answer 45

oxygen binding proteins like myoglobin and hemoglobin

Question 46

what group do myoglobin and hemoglobin require

Answer 46

heme

Question 47

consists of complex organic ring structure with a bound Fe2+ atom

Answer 47

heme

Question 48

highly conserved tertiary structure with 8 alpha helical segments connected by bends

Answer 48

globins

Question 49

most globes function in what

Answer 49

O2 transport or storage

Question 50

153 residues and 1 molecule of heme

Answer 50

myoglobin

Question 51

oxygen carrier in the muscle

Answer 51

myoglobin