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Flashcards in depression 1 Deck (23)
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1

what black box warning is on all anti-derpressants

increase risk of suicidal ideation (due to increase of energy)

2

what are the monoamines

serotonin
dopamine
norepinephrine

3

what are 3 forms of non-pharm therapy for depression

1. psychotherapy
2. ECT
3. bright light therapy

4

what are the contraindications for use of SSRIs

1. use of an MAOI or use of MAOI within 14 days
2. 5 week washout for fluoxetine
3. concurrent use with linezolid or IV methylene blue

5

why are SSRI's first line for depression

safety and tolerability

6

what are some side effects of SSRI's

sexual dysfunction, nausea, and vomiting

7

what SSRI's have the largest risk for QTc prolongation risk

1. citalopram
2. escitalopram
3. paroxetine

8

what SSRI is a pregnancy category D drug

paroxetine

9

list 3 CYP 2D6 inhibiting SSRI's

1. paroxetine
2. fluoxetine
3. sertraline

10

what is an SSRI with a major side effect of diarrhea

sertraline (Zoloft)

11

what SSRI is indicated primarily for OCD disorder (not MDD)

fluvoxamine (Luvox)

12

what should be counseled for all SSRI's

1. GI distrubances (n/v/d)
2. CNS effects (anxiety, headache, insomnia, depression)
3. sexual dysfunction

13

What SNRI side effect is not seen in SSRIs

dose dependent increase in blood pressure

14

doses of venlafaxine greater than 150 mg have what effect

blocks norepinephrine causing hypertension

15

True/ False:
desvenlafaxine shows no benefit over venlafaxine

True

16

what SNRIs are indicated for fibromyalgia

duloxetine
milnacipran

17

why should SNRI's not be d/c'd abruptly

withdrawal syndrome of flu like symptoms

18

what are the indications of bupropion

1. MDD (first line)
2. social anxiety disorder
3. smoking cessation

19

what is the MOA of bupropion

metabolite that acts as a norepinephrine and dopamine reuptake inhibitor

20

what antidepressant can not cause serotonin syndrome

bupropion (no effect on serotonin)

21

what are the contraindications of bupropion

1. history of seizures
2. eating disorder
3. electrolyte imbalance

22

who should use caution when using bupropion

alcoholics, and patients with a history of mania or psychosis

23

what are the adverse effects of bupropion

1. seizure
2. dry mouth
3. constipation
4. weight loss