Flashcards in depression 1 Deck (23)
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1
what black box warning is on all anti-derpressants
increase risk of suicidal ideation (due to increase of energy)
2
what are the monoamines
serotonin
dopamine
norepinephrine
3
what are 3 forms of non-pharm therapy for depression
1. psychotherapy
2. ECT
3. bright light therapy
4
what are the contraindications for use of SSRIs
1. use of an MAOI or use of MAOI within 14 days
2. 5 week washout for fluoxetine
3. concurrent use with linezolid or IV methylene blue
5
why are SSRI's first line for depression
safety and tolerability
6
what are some side effects of SSRI's
sexual dysfunction, nausea, and vomiting
7
what SSRI's have the largest risk for QTc prolongation risk
1. citalopram
2. escitalopram
3. paroxetine
8
what SSRI is a pregnancy category D drug
paroxetine
9
list 3 CYP 2D6 inhibiting SSRI's
1. paroxetine
2. fluoxetine
3. sertraline
10
what is an SSRI with a major side effect of diarrhea
sertraline (Zoloft)
11
what SSRI is indicated primarily for OCD disorder (not MDD)
fluvoxamine (Luvox)
12
what should be counseled for all SSRI's
1. GI distrubances (n/v/d)
2. CNS effects (anxiety, headache, insomnia, depression)
3. sexual dysfunction
13
What SNRI side effect is not seen in SSRIs
dose dependent increase in blood pressure
14
doses of venlafaxine greater than 150 mg have what effect
blocks norepinephrine causing hypertension
15
True/ False:
desvenlafaxine shows no benefit over venlafaxine
True
16
what SNRIs are indicated for fibromyalgia
duloxetine
milnacipran
17
why should SNRI's not be d/c'd abruptly
withdrawal syndrome of flu like symptoms
18
what are the indications of bupropion
1. MDD (first line)
2. social anxiety disorder
3. smoking cessation
19
what is the MOA of bupropion
metabolite that acts as a norepinephrine and dopamine reuptake inhibitor
20
what antidepressant can not cause serotonin syndrome
bupropion (no effect on serotonin)
21
what are the contraindications of bupropion
1. history of seizures
2. eating disorder
3. electrolyte imbalance
22
who should use caution when using bupropion
alcoholics, and patients with a history of mania or psychosis
23
