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Flashcards in headache 1 Deck (16)
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1

what are the 3 primary headache disorders

1. migraine
2. tension
3. cluster

2

what are 3 secondary headache disorders

1. head trauma
2. vascular disorders
3. substance use

3

what type of headache is like a tornado, hits fast and reaks havoc...

migraine

4

what are 4 adjectives for describing a migraine

recurring
throbbing
unilateral
severe

5

what is an aura associated with a migraine

neurological attack that precedes the headache (usually visual impairment)

6

what are the two theorys of the pathophysiology of headaches

1. vascular theory -intracranial vasoconstriction (aura) and rebound vasodilation (headache)
2. neurovascular theory - complex neural and vascular events

7

what are the 3 components of neurovascular theory of migranes

1. neuronal hyperexcitability - lower threshold for developing migraine
2. cortical spreading depression - neuroelectrical process of excitation followed by suppression
3. trigeminovascular system - release vasoactive neuropeptides

8

what neurological event causes aura

cortical spreading depression

9

where does cortical spreading depression

occipital lobe

10

what directly correlates with development of aura

rate of cortical spreading depression constriction (2-3 mm/minute)

11

what 3 vasoactive neuropeptides are released by nerves in the trigeminovascular system

1. calcitonin gene-related peptide (CGRP)
2. substance P
3. neurokinin A

12

what is the most common vasoactive neuropeptide

calcitonin gene-related peptide (CGRP)

13

what physiological effects do neuropeptides have

1. vasodilation
2. extravasation of plasma and plasma proteins
3. mechanical stretching (edema)
4. pain

14

what physiological effects do neuropeptides have termed as neurogenic inflammation

1. vasodilation
2. extravasation of plasma and plasma proteins
3. mechanical stretching (edema)

15

what regulates the trigeminovascular system

serotonin

16

activation of what causes migraines

trigeminovascular system