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Therapeutics III Test 3 > schizo > Flashcards

Flashcards in schizo Deck (17)
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1

what are comorbid conditions with schizophrenia

1. depression
2. anxiety
3. substance abuse
4. general medical disorders

2

blockade of what dopaminergic tract results in antipsychotic effects

mesolimbic

3

what is the major desired effect of pharmacotherapy w schizophrenia

avoid unwanted side effects using minimum effective dose

4

list the 1st gen antipschotics

haloperidol
chlorpromazine
fluphenazine
loxapine
perphenazine
thioridazine
thiothixene
trifluoperazine

5

first generization antipsychotics work for what symptoms

positive, not negative

6

low potency antipsychotics have low affinity to what

D2 receptors

7

what is the high potency antipsychotics (need low mg doses)

haloperidol
thiothixene
fluphenazine
trifluorperazine

8

what are the extrapyramidal symptoms

parkinsonism
dystonia
akathisia

9

what is an inability to stay still or calm

akathisia

10

what drug helps with long term complications of antipsychotics

clozaril

11

what is neurolepticmalignant syndrome

occurs with high potency drugs (haloperidol)

12

what are differences in serotonin syndrome and neuroleptic malignant syndrome

NMS has slow onset (7 days)
NMS has incontinence
NMS has hyperthermia
NMS is more deadly

13

what causes hyperprolatinemia with antipsychoitics

D2 blockade in tuberinfunibular (usually drugs that end in -done... risperidone)

14

what antipsychotic cuses the worst qtc prolongation

thioridazine and ziprasidone

15

what antipsychotic drug is category X with levofloxacin

ziprasidone

16

how does dosing of haloperidol decanoate relate to PO haloperidol

10-20 times first dose

17

why should haloperidol not be given IV

torsades de pointes