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Therapeutics III Test 3 > Bipolar 4 > Flashcards

Flashcards in Bipolar 4 Deck (18)
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1

when are CBC's needed for patients on valproic acid

1. CBC at baseline
2. every month for 6 months
3. every 6 months after

2

what are the BBWs of depakote

1. hepatotoxicity
2. hemorrhagic pancreatitis
3. teratogenicity

3

when benefits outweigh risks with a pregnant patient, what should be given with depakote

5 mg of folic acid; decreases neural tube defects

4

what drug interactions can cause decreased valproic acid concentrations

1. carbamazepine
2. lamotrigine
3. phenytoin

5

what drug interactions can cause an increase in valproic acid concentrations

1. clarithromycin
2. erythromycin
3. felbamate
4. isoniazid

6

what is the only indication for lamotrigine in treating bipolar disorder

only maintenance therapy for type I Bipolar disorder

7

what drug is most effective for preventing bipolar depression

lamotrigine

8

what is the initiating dose of lamotrigine

25 mg/day for 2 weeks (to decrease AEs)

9

what are the two most common side effects with lamotrigine

rash
steven johnsons syndrome

10

what is the goal dose of lamotrigine

200mg per day

11

what effect does valproic acid have on lamotrigine concentrations

prolongs the half life of lamotrigine; increasing lamotrigine conentration

12

what is the initiating dose of lamotrigine for patients on depakote

25 mg every other day

13

what is the initial dose of lamotrigine for patients on carbamazepine, phenytoin, phenobarbital, or oral contraceptives?

50 mg/ day for 2 weeks

14

what drug interactions decrease lamotrigine concentrations

1. carbamazepine
2. phenytoin
3. phenobarbital
4. oral contraceptives

15

initiation of lamotrigine can't be within two weeks of what

viral infection
rash
vaccination

16

what are the concentration dependent adverse effects of lamotrigine

1. nausea
2. headache
3. drowsiness
4. diplopia
5. headache

17

what is the idiosyncratic adverse effect most commonly associated with lamotrigine

rash

18

what is a positive trait of lamotrigine that makes it stand out from other options

weight neutral