Diseases and health monitoring in laboratory animals Flashcards Preview

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Flashcards in Diseases and health monitoring in laboratory animals Deck (8):
1

Name some causes of disease

  • infections
  • age
  • tumours
  • immune system
  • metabolic
  • behaviour
  • environment
  • parturition
  • developmental defects
  • iatrogenic
  • genetics

2

Name some consequences of disease

They have consequences on

  • immune response
  • growth rate
  • tumour development
  • behaviour
  • longevity
  • fertility

3

How may immunodeficient animals differ from "normal" ones?

  • Disease
    • clinical course
    • duration
    • chronic carriers
    • clinical signs are often unspecific
    • subclinical disease is common
  • lesions
    • severity
    • characteristic lesions not always present
    • unusual pathologies

4

What does gnotobiotic mean?

  • a controlled environment containing one or a few kinds of organisms
  • free from other living organisms
  • can be
    • specific pathogen free
    • germ-free

5

What are sentinels?

Microbiologically defined animals introduced into an animal group for surveillance purposes

6

When are sentinels used?

  • normal animals
  • serology is not possible or unreliable
  • few or valuable animals
  • along prolonged experiments
  • suspicion of disease
  • to test that control measures adopted for eradicating agents were successful

7

What is health monitoring?

  • laboratory tests
  • active search for organisms
  • defines status regarding specific infectious diseases
  • apparently healthy animals

8

When are diagnostic necropsies performed?

  • disease or mortality
  • unexpected experimental results
  • circumstancial evidence that something may have happened: transportation, dietary changes, environmental monitoring, barrier failure etc.