Flashcards in diseases of the motor unit Deck (54)
most common type of diabetic neuropathy
distal symmetric polyneuropathy
EMG can distinguish what?
b/w axonal and demyelinating neuropathy
fluctuating weakness, incr with exertion and improved with rest; diplopia, ptosis
___extremities are more commonly affected by muscle weakness in myasthenia gravis
respiratory failure secondary to intercostal and diagphragmatic weakness
myasthenia gravis pathophys is due to anti_____Ab that block _____synaptic receptros
anti-ACh Ab that block post synaptic receptors
pharmacologic dx of myasthenia gravis
edrophonium test blocks AChE
T or F: Ab titers indicate disease severity of MG
what can be used for sx tx of MG?
cholinesterase inhibs (mestinon)
besides tx of guillain barre, plasmapharesis and IVIG can be used to tx what?
the hallmark of myopathy is _____
weakness that is symmetric and proximal, neck flexor weakness, waddling gait
what marker is often elevated in myopathy
painless subacute proximal weakness with dysphagia, neck weakness that spares eyes, face
biopsy changes expected with polymyositis
Ag specific cytotoxic t cells, direct muscle fiber damage
subacute proximal weakness with heliotrope rash, Grotton's patches
Ab against endothelial cells dx what?
weakness over years, quadriceps weakness, no respose to immunosuppressive agents
inclusion body myositis
steroid myopathy can present when on doses prednisone >____ for >_____montsh
>30 mg QD for >2 months
any muscle complaint related to statins
muscle complaints w/o CK elevation
muscle sx w/ CK elevation
CK elevation >10x normal with incr Cr