Flashcards in diseases of the motor unit Deck (54)
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31
most common type of diabetic neuropathy
distal symmetric polyneuropathy
32
EMG can distinguish what?
b/w axonal and demyelinating neuropathy
33
fluctuating weakness, incr with exertion and improved with rest; diplopia, ptosis
myasthenia gravis
34
___extremities are more commonly affected by muscle weakness in myasthenia gravis
upper
35
respiratory failure secondary to intercostal and diagphragmatic weakness
myasthenic crisis
36
myasthenia gravis pathophys is due to anti_____Ab that block _____synaptic receptros
anti-ACh Ab that block post synaptic receptors
37
pharmacologic dx of myasthenia gravis
edrophonium test blocks AChE
38
T or F: Ab titers indicate disease severity of MG
FALSE
39
what can be used for sx tx of MG?
cholinesterase inhibs (mestinon)
40
besides tx of guillain barre, plasmapharesis and IVIG can be used to tx what?
myasthenic crisis
41
the hallmark of myopathy is _____
weakness
42
weakness that is symmetric and proximal, neck flexor weakness, waddling gait
myopathy
43
what marker is often elevated in myopathy
CK
44
painless subacute proximal weakness with dysphagia, neck weakness that spares eyes, face
polymyositis
45
biopsy changes expected with polymyositis
Ag specific cytotoxic t cells, direct muscle fiber damage
46
subacute proximal weakness with heliotrope rash, Grotton's patches
dermatomyositis
47
Ab against endothelial cells dx what?
dermatomyositis
48
weakness over years, quadriceps weakness, no respose to immunosuppressive agents
inclusion body myositis
49
steroid myopathy can present when on doses prednisone >____ for >_____montsh
>30 mg QD for >2 months
50
any muscle complaint related to statins
statin myopathy
51
muscle complaints w/o CK elevation
myalgia
52
muscle sx w/ CK elevation
myositis
53
CK elevation >10x normal with incr Cr
rhabdomyolysis
54
