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Flashcards in diseases of the motor unit Deck (54)
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31

most common type of diabetic neuropathy

distal symmetric polyneuropathy

32

EMG can distinguish what?

b/w axonal and demyelinating neuropathy

33

fluctuating weakness, incr with exertion and improved with rest; diplopia, ptosis

myasthenia gravis

34

___extremities are more commonly affected by muscle weakness in myasthenia gravis

upper

35

respiratory failure secondary to intercostal and diagphragmatic weakness

myasthenic crisis

36

myasthenia gravis pathophys is due to anti_____Ab that block _____synaptic receptros

anti-ACh Ab that block post synaptic receptors

37

pharmacologic dx of myasthenia gravis

edrophonium test blocks AChE

38

T or F: Ab titers indicate disease severity of MG

FALSE

39

what can be used for sx tx of MG?

cholinesterase inhibs (mestinon)

40

besides tx of guillain barre, plasmapharesis and IVIG can be used to tx what?

myasthenic crisis

41

the hallmark of myopathy is _____

weakness

42

weakness that is symmetric and proximal, neck flexor weakness, waddling gait

myopathy

43

what marker is often elevated in myopathy

CK

44

painless subacute proximal weakness with dysphagia, neck weakness that spares eyes, face

polymyositis

45

biopsy changes expected with polymyositis

Ag specific cytotoxic t cells, direct muscle fiber damage

46

subacute proximal weakness with heliotrope rash, Grotton's patches

dermatomyositis

47

Ab against endothelial cells dx what?

dermatomyositis

48

weakness over years, quadriceps weakness, no respose to immunosuppressive agents

inclusion body myositis

49

steroid myopathy can present when on doses prednisone >____ for >_____montsh

>30 mg QD for >2 months

50

any muscle complaint related to statins

statin myopathy

51

muscle complaints w/o CK elevation

myalgia

52

muscle sx w/ CK elevation

myositis

53

CK elevation >10x normal with incr Cr

rhabdomyolysis

54

asymmetric, variable location of motor sx, atrophy, fasciculations

motor neuron disease