Drugs Flashcards Preview

Pharmacology 3 > Drugs > Flashcards

Flashcards in Drugs Deck (34):
1

Rimantadine is poor at crossing the? and has less what?

BBB CNS effects

2

Warfarin 

MOA 

how to monitor 

AE

  • Inhibits vitamin K epoxide reductase 
  • Teratogenic-fetal hemorrhage 

3

Dipyridamole

  • Inhibits reuptake of adenosine and inhibits phosphodiester that degrades cAMP
  • Contraindicated in CHF 

4

Nonnucleotide RTI are different than side and tide inhibitors in what way?

Dont require phosphorylation 

Dont compete with dNTPs

Resistance develops rapidly 

5

Activated partial thromboplastin time deals with what meds?

Heparin, also helpful in diagnosis of hemophilia

6

What does amantadine block?

Blocks the M2 proton ion channel

7

Rudins are? Monitored by?

Direct thrombin inhibitors Monitored by aPTT same as Heparin

8

Direct oral Factor Xa inhibitors?

xabans A fib - Cant be reversed

9

Tenofovir inhibits?

viral reverse transcriptase DNA chain terminator 

10

Clopidogrel 

MOA

DI 

  • Irreversible inhibition of platelet ADP receptor 
  • Bleeding GI 

11

Zidovudine ZDV or AZT 

AE

  • Bone marrow toxicity causing anemia 
  • Lactic acidosis 

12

If someone takes too much warfarin what do you do?

Vitamin K

13

Heparin is reversed by?

Proxamine

14

Rimantadine is a?

Uncoating inhibitor

15

Apixaban is a ______

Direct factor Xa inhibitors

16

Oseltamivir is a?

Inhibitor of influenza neuraminidase oral

17

Nucleoside RT inhibitors need to be activated by?

  • Need to be activated within the cell by phosphorylation 

18

Clopidogrel

  • Irreversible inhibition of platelet ADP receptor 
  • Bleeding, GI 

19

Tenofovir?

Nucleotide RTI

20

Plase

Drugs that activate tissue plasminogen to create plasmin Given soon after event

21

Rimantadine is ___ compared to amantadine

longer lived

22

Plase drugs do what?

Activate plasminogen to plasmin

23

Nevirapine, delavirdine and efavirenz are?

MOA

AE

  • NNRTI
  • They are not active against HIV-2 
  • NNRTIs bind directly noncompetitively to the RT enzyme at a site distinct from NRTI binding site 
  • Block DNA polymerase by causing a conformational change and disrupt the catalytic site of the enzyme 

24

Tipranavir 

 

  • Antiretroviral protease inhibitor 
  • non-peptidic protease inhibitor 
  • AE
    • Dose-dependent hepatotoxicity, lipodytrophy 

25

Nucleotide RTI differ from nucleoside analogs in what way?

They are already phosphorylated so they can skip the nucleoside-kinase reaction 

26

Zidovundine ZDV or AZT is a?

Nucleoside ot tide?

NRTI

27

How do nucleoside reverse transcriptase inhibitors cause termination of viral growth 

  • The lack of 3'-OH analog prevents the formation of the 5' to 3' phosphodiester linkage needed for chain elongation 

28

Integrase inhibitors?

Raltegravir, prevent virus DNA from integrating into host genome

29

Aspirin MOA Drug interactions and AE

  • Irreversible COX1 inhibitor Reduces the production of thromboxane A2
  • Can cause nephrotoxicity 

30

Ritonavir?

MOA

DI AE

 

  • Antiretroviral protease inhibitor 
  • Competitive inhibitor of HIV protease responsible for cleaving gag-pol precursor molecule
  • Inhibit both HIV-1 and 2 

DI

  • Ritonavir is a substrate and potent inhibitor of CYP3A4 
  • Can act as a pharmacokinetic enhancer of drug metabolized by CYP450 3A 

AE 

  • Hyperlipidemia, with large increases in total cholesterol and TG concentrations 

31

Abciximab

MOA

AE DI

 

 

  • Inhibits platelet aggregation by interfering with GPIIb/IIIa binding to fibrinogen and other ligands 
  • Bleeding thrombocytopenia with prolonged use 

32

Oseltamivir blocks?

Neuraminidase

33

Lamivudine 3TC 

As well as being used for HIV can also inhibit replication of?

Side or tide?

 

NRTI

HBV

34

Maravoroc?

HIV entry inhibitor that stops binding with CCR5 receptor - Can interfere with immune response, not effective at all with CXCR4 because CCR5 isnt used