Quiz 2 Flashcards Preview

Pharmacology 3 > Quiz 2 > Flashcards

Flashcards in Quiz 2 Deck (31):
1

Antiplatelet Factors Secreted by ____ ? Promote ____? Inhibit _______ ?

Endothelial Cells Vasodilation Platelet adhesion and aggregation

2

Prostacyclin PGI2 Signal with _____ Opposes the effects of _____?

cAMP TXA2

3

Nitric Oxide signals with_____?

cGMP-vasodilation

4

What are the 4 antithrombotic activities?

- Heparan sulfate anchors Antithrombin III (ATIII) - ATIII inactivates Xa, IXa, XIa, and XIIIa - Tissue factor pathway inhibitor (TFPI) - Thrombin-thrombomodulin complex activates protein C (C) + Protein C and protein S cleave Va, VIIIa and activate t-PA

5

Antithrombin III Looks like _____? Is a ______ of serine proteases including these 5 clotting factors

Inactive clotting factors - It is a suicide substrate Thrombin, IX, X, XI, XII

6

Antithrombin is clinically activated by ____ what medicine?

Heparin - Indirect

7

Tissue factor pathway inhibitor does what?

Blocks Tissue factor which blocks the whole pathway

8

What protein complex inactivates the inhibitor of t-PA

Protein C/S

9

What does t-PA do? What is the end result?

Turns Plasminogen into plasmin Result is digestion of fibrin clot

10

Only one type of heparin can inhibit II

Unfractionated heparin

11

Thrombomodulin----> _____------>_______ ----->______? Activates _____ ---- _____? This is called?

Thrombin APC/PS complex t-PA Plasminogen ----> Plasmin Fibrinolysis

12

t-PA can be activated by both _____ and _____

Protein C/S complex and fibrin

13

What are the Antiplatelet drugs

- Aspirin - Clopidogrel -Dipyridamole (increases cAMP, and cGMP) -Abciximab, eptifibatide, tirofiban GPIIb,a blockage

14

What are the anticoagulant drugs?

Heparins DTIs Warfarin Factor Xa inhibitors

15

Unfractionated heparin works against?

Factor X and factor II Can cause HIT

16

Pentasaccharide, and low molecular weight heparindont act on? What is the reeason for this?

Factor II thrombin reduce the risk of HIT Indirect through antithrombin III

17

Warfarin Induces ____ deficiency?

Vitamin K deficiency

18

What is the target of warfarin?

Epoxide Reductase

19

Warfarin has delayed _____ and ______

Onset and off set, Teratogenic

20

What are the two tests that need to be done when a patient is on Warfarin? When do these tests need to be done?

Prothrombin Time ( Before and after taking) International Normalized Ratio - Pt is converted into this through division

21

Activated partial thromboplastin time deals with what meds?

Heparin, also helpful in diagnosis of hemophilia

22

If someone takes too much warfarin what do you do?

Vitamin K

23

Apixaban is a ______

Direct factor Xa inhibitors

24

Rudins are? Monitored by?

Direct thrombin inhibitors Monitored by aPTT same as Heparin

25

Plase drugs do what?

Activate plasminogen to plasmin

26

What are the adverse effects of Recombinant tissue-plasminogen activators?

Cardiac Arrythmias Intracranial, GI bleeding Cholesterol Embolization

27

What are the contraindications for Fibrinolytic therapy?

-Prior intracranial hemorrhage - Known structural cerebral vascular lesion - Known malignant intracranial neoplasm - Ischemic stroke within 3 months -Active bleeding or bleeding diathesis - Closed head trauma or facial trauma within

28

Heparin is reversed by?

Proxamine

29

Dipyridamole

Inhibits reuptake of adenosine and inhibits phosphodiester that degrades cAMP

30

Direct oral Factor Xa inhibitors?

xabans A fib - Cant be reversed

31

Plase

Drugs that activate tissue plasminogen to create plasmin Given soon after event