One is specific for upper and lower respiratory tract infections?
Ciprofloxacin, Levofloxacin, floxacin
Terbinafine and Azoles both block synthesis of?
Blocks Dihydrofolate reductase
Block dihydropteroate synthase
Sulfonamides are good for?
Generally use as?
- Uncomplicated UTIs
- Hematopoietic disturbances
- interacts with warfarin
Adverse effects of Fluoroquinolones?
How do they work?
- Prolonged QT
- Cartilage degradation, Achilles tendon
- Should be avoided during pregnancy
They block bacterial DNA synthesis by inhibiting bacterial topoisomerase II (DNA gyrase) and Topo IV
Combination of sulfonamide with timethoprim is?
Synergistic becasue it blocks the process in two different steps.
How to fungal infections invade and evade destruction
- Intracellular survival (switch from yeast to more virulent)
- Inhibit phagocytosis
- Antigenic Variation
- Immune suppression
- Tissue damage by triggering inflammatory response
Disease caused by fungi?
Fungi that invade the skin, hair, or nails? They are specifically called?
Deep fungal infections are ____ threatening
dermatophytes, tineas (ringworm)
Polyene macrolide like amphotericin B
is too toxic for parenternal admin and only used topically
WHAT IS THIS?
Rifamycin is a?
What is its MOA?
Antimycobacterial Drug that inhibits the synthesis of RNA by targeting RNA polymerase
Using ABXs can cause?
Medical devices can also cause _____ invasion
_____ is a major cause of fungal sepsis and septic shock (HTN, tachycardia)
Binds to ergosterol in the fungal cell membrane forming pores
- Broad spectrum with good activity against candida, cryptococcus
AE: Infusion related rxns, nephrotoxicity.
Oral and topical fungicidal that blocks ergosterol synthesis at an earlier step than azoles
Oral fungistatic used for dermatophytosis
Blocks DNA and RNA polymerization
Treats Cryptococcus associated meningitis
Bone marrow toxicity with anemia, leukopenia, and thrombocytopenia
Inhibits fungal wall synthesis, good for invasive candidiasis
Grow as ovoid or spherical, single cells multiply by budding and division
- Eukaryotic Cells with _____ walls
- Can grow as molds or yeasts
- ______ can be both
- Resistant to ________ wall
- Rigid cell walls
- Candida albicans
- bacterial cell wall inhibitors
- Can adapt to a wide variety of temperatures, digest keratin, low oxygen, they also suppress the immune systems defense
Isoniazid is responsible for?
Cell wall inhibition of mycobacteria it inhibits mycolic acid synthesis
Inhibition of protein synthesis by targeting the 30S ribosomal subunit.
Used as an Anti what?
Block ergosterol synthesis from lanosterol
broad spectrum for candida, C neoformans, endemic mycoses
Metabolized by CYP3A4
Maturatio of TB
A fungal infection is also referred to as?
Filamentous fungi growth as multinucleate, branching hyphae (branching), ringworm is a common one. Also these are more pathogenic
Why are mycobacteria (like TB) difficult to treat?