Muma Quiz 1 GI

Question 1

Antacids Neutralize? Taken when and lasts for? Can affect the absorption of?

Answer 1

Neutralize gastric acid, taken 1 hr after meal effective for up to 2 hrs. Can affect absorption of drugs by direct binding or via increasing gastric pH.

Question 2

Sodium bicarbonate What does it do? Brand names?

Answer 2

Reacts with HCl to produce NaCl and CO2 which causes belching and gastric distention. Baking soda, Alka Seltzer

Question 3

Magnesium hydroxide & Aluminum hydroxide What does it do what are the brand names?

Answer 3

Maalox, Mytanta, Gelusil Reacts with HCl to form water and aluminum chloride or magnesium chloride. Magnesium salts not absorbed can cause osmotic diarrhea and aluminum salts can cause constipation so often used together.

Question 4

H2 receptor antagonists

Answer 4

Cimetidine

Question 5

Pharmaco kinetics of H2 receptor antagonists all but which one undergoes?

Answer 5

All but nizatidine under-go first pass metabolism resulting in 50% bioavailability. Cleared by both metabolism and excretion so need for dose reduction with severe renal dysfunction.

Question 6

Pharmacodynamics of H2receptor antagonists

Answer 6

Highly selective H2 competitive antagonists which inhibit meal-stimulated but especially basal nocturnal gastric acid secretion and pepsin. Inhibit 60-70% of acid secretion per day.

Question 7

H2 receptor antagonists AEs

Answer 7

Extremely safe, < 3% diarrhea, constipation, headache fatigue, myalgias In elderly in intensive care or renal or hepatic dysfunction- mental status perturbation Cimetidine inhibits binding of dihydrotestosterone to androgen receptors and estradiol metabolism so increases serum prolactin resulting in possible male gynecomastia or impotence and female galactorrhea. Cross placenta and excreted in breast milk

Question 8

DIs of H2 antagonists

Answer 8

Competes with creatinine and with some drugs for renal tubule secretion Cimetidine inhibits P450 drug metabolism

Question 9

Definitions of the 3 diseases of acid-peptic diseases

Answer 9

Question 10

Factors that Protect (6) and Damage (9)

Answer 10

Question 11

Parietal cell acid secretion

Answer 11

Question 12

H. Pylori in Duodenal Peptic Ulcer Disease

What environment does it live in?

What does it do?

What does it produce?

What does this product cause?

What on the surface of this causes inflammation?

Answer 12

Question 13

NSAIDS in Peptic Ulcer Disease

What type of inhibitor?

What type of inhibition is the biggest issue?

How does local injury happen?

Mortality?

Answer 13

Question 14

Drugs used for Acid-peptic diseases

Drugs that reduce gastic acidity 3

and Mucosal protecting agents 3

Answer 14

Question 15

Antacids 4

Answer 15

1. Sodium Bicarb
2. Calcium Carbonate
3. Mg Hydroxide
4. Aluminum hydroxide

Question 16

H2 receptor antagonists 4 only need to know one

all are ___ except for?

Answer 16

Question 17

PPIs

5

What types of drugs are these?

Answer 17

Question 18

Mucosal Protecting Agents

3

Answer 18

Question 19

Abx for the tx of helicobacter pylori-associated ulcers

4

only need to know 2

Answer 19

Question 20

Overview of drug site of action

Answer 20

Question 21

Laxative bulk forming

Answer 21

Question 22

Bulk forming laxative 3

Answer 22

Question 23

Stool Softeners

3

Answer 23

Question 24

Osmotic Laxatives

4

Answer 24

Question 25

Stimulant laxatives 2 types

Answer 25

Question 26

Chloride Channel Activator

Answer 26

Lubiprostone

Question 27

Opioid receptor antagonists

Answer 27

Question 28

5-HT4 agonists

Answer 28

Prucalopride

Question 29

Guanylate cyclase agonists

Answer 29

* Plecanatide, Linaclotide

Question 30

Antidiarrheals

Answer 30

Question 31

Opioid agonists

Answer 31

Loperamide, Diphenoxylate

Question 32

Bismuth compounds

Answer 32

* Bismuth subsalicylate * Nismuth subcitrate potassium

Question 33

Kaolin and pectin?

Answer 33

Chalk and Apples?

Question 34

Bile-salt binding resins

Answer 34

Question 35

Octreotide

Answer 35

Question 36

Antiemetics regulations of?

Answer 36

Question 37

Antiemetics 8

Answer 37

Question 38

5-HT3 antagonists

Answer 38

Question 39

Corticosteroids

Answer 39

Question 40

Neurokinin 1 receptor antagonists

Answer 40

Question 41

D2 dopmaine antagonists

Answer 41

Question 42

Substituted benzamides

Answer 42

Question 43

H1 antihistamine and anticholinergics

Answer 43

Question 44

Benzos 2

Answer 44

Loraz, Diaz

Question 45

Cannabinoids

Answer 45

Bronabinol Nabilone

Question 46

IBS Chronic ___ disorder \_\_\_\_ discomfort and? Both or neither? Disorder that doesnt lead to? Caused by? Prevalence?

Answer 46

Question 47

Types of IBS 4

Answer 47

Question 48

Treatment of IBS with Diarrhea

Answer 48

Question 49

IBS with constipation

Answer 49

Question 50

Lifestyle and Alternative medicine for IBS Avoid or reduce? 4 other things

Answer 50

Question 51

Low FODMAPs Diet What does it stand for? What are they? What does this lead to?

Answer 51

Question 52

IBD Chronic disease that causes? How does it begin? periods of? What is the goal of therapy?

Answer 52

Question 53

IBD 2 types * Inflammation usually extends from the mucosa through the entire thickness of the bowel wall * Inflammation limited to the mucosa of the colon * Inflammation limited to the colon * Can affect any area of the GI tract from the mouth to the anus * Thuse fistulas, abscesses or strictures of the bowel much less common * Thus may lead to fistulas, abscesses or strictures of the bowel much less common

Answer 53

Question 54

Symptoms of IBD Most common symptoms are? Other symptoms are? Inflammation outside the GI can cause? Children with the disease may have?

Answer 54

Question 55

IBD OTC tx 3 things

Answer 55

Question 56

Rx med for IBD

Answer 56

Question 57

Aminosalicylates

Answer 57

Question 58

Targeting Aminosalicylates

Answer 58

Question 59

Glucocorticoids

Answer 59

Question 60

Immunomodulators

Answer 60

And methotrexate

Question 61

Anti-Tumor necrosis factor

Answer 61

*

Question 62

Anti-integrin

Answer 62

Question 63

Abx for IBS

Answer 63

Question 64

Celiac Disorder \_\_\_ - mediated intestinal disorder Characterized by? Predisposed? Dietart proteins in?

Answer 64

Question 65

Diagnosis of Celiac Disease How does it present What type of testing? Biopsy where?

Answer 65

Question 66

Tx for celiac disease Life long? Initially? Refractory disease?

Answer 66