Muma Quiz 1 GI Flashcards Preview

Pharmacology 3 > Muma Quiz 1 GI > Flashcards

Flashcards in Muma Quiz 1 GI Deck (66):
1

Antacids Neutralize? Taken when and lasts for? Can affect the absorption of?

Neutralize gastric acid, taken 1 hr after meal effective for up to 2 hrs. Can affect absorption of drugs by direct binding or via increasing gastric pH.

2

Sodium bicarbonate What does it do? Brand names?

Reacts with HCl to produce NaCl and CO2 which causes belching and gastric distention. Baking soda, Alka Seltzer

3

Magnesium hydroxide & Aluminum hydroxide What does it do what are the brand names?

Maalox, Mytanta, Gelusil Reacts with HCl to form water and aluminum chloride or magnesium chloride. Magnesium salts not absorbed can cause osmotic diarrhea and aluminum salts can cause constipation so often used together.

4

H2 receptor antagonists

Cimetidine

5

Pharmaco kinetics of H2 receptor antagonists all but which one undergoes?

All but nizatidine under-go first pass metabolism resulting in 50% bioavailability. Cleared by both metabolism and excretion so need for dose reduction with severe renal dysfunction.

6

Pharmacodynamics of H2receptor antagonists

Highly selective H2 competitive antagonists which inhibit meal-stimulated but especially basal nocturnal gastric acid secretion and pepsin. Inhibit 60-70% of acid secretion per day.

7

H2 receptor antagonists AEs

Extremely safe, < 3% diarrhea, constipation, headache fatigue, myalgias In elderly in intensive care or renal or hepatic dysfunction- mental status perturbation Cimetidine inhibits binding of dihydrotestosterone to androgen receptors and estradiol metabolism so increases serum prolactin resulting in possible male gynecomastia or impotence and female galactorrhea. Cross placenta and excreted in breast milk

8

DIs of H2 antagonists

Competes with creatinine and with some drugs for renal tubule secretion Cimetidine inhibits P450 drug metabolism

9

Definitions of the 3 diseases of acid-peptic diseases

10

Factors that Protect (6) and Damage (9)

11

Parietal cell acid secretion 

12

H. Pylori in Duodenal Peptic Ulcer Disease 

What environment does it live in? 

What does it do?

What does it produce?

What does this product cause?

What on the surface of this causes inflammation? 

13

NSAIDS in Peptic Ulcer Disease

What type of inhibitor?

What type of inhibition is the biggest issue?

How does local injury happen?

Mortality?

14

Drugs used for Acid-peptic diseases

Drugs that reduce gastic acidity  3

and Mucosal protecting agents 3

15

Antacids 4 

  1. Sodium Bicarb
  2. Calcium Carbonate
  3. Mg Hydroxide 
  4. Aluminum hydroxide 

16

H2 receptor antagonists 4 only need to know one 

all are ___ except for? 

17

PPIs

5

What types of drugs are these?  

18

Mucosal Protecting Agents 

3

19

Abx for the tx of helicobacter pylori-associated ulcers 

only need to know 2 

20

Overview of drug site of action 

21

Laxative bulk forming 

 

22

Bulk forming laxative 3 

23

Stool Softeners 

3

24

Osmotic Laxatives 

25

Stimulant laxatives 

2 types 

26

Chloride Channel Activator 

Lubiprostone

27

Opioid receptor antagonists

28

5-HT4 agonists 

Prucalopride 

29

Guanylate cyclase agonists

  • Plecanatide, Linaclotide 

30

Antidiarrheals 

31

Opioid agonists 

Loperamide, Diphenoxylate 

32

Bismuth compounds 

  • Bismuth subsalicylate 
  • Nismuth subcitrate potassium 

33

Kaolin and pectin?

Chalk and Apples?

34

Bile-salt binding resins 

35

Octreotide 

36

Antiemetics regulations of? 

37

Antiemetics 

8

38

5-HT3 antagonists 

39

Corticosteroids 

40

Neurokinin 1 receptor antagonists 

41

D2 dopmaine antagonists

42

Substituted benzamides 

43

H1 antihistamine and anticholinergics 

44

Benzos

Loraz, Diaz

45

Cannabinoids 

Bronabinol

Nabilone 

46

IBS 

Chronic ___ disorder

____ discomfort and? Both or neither?

Disorder that doesnt lead to?

Caused by?

Prevalence? 

47

Types of IBS 4

48

Treatment of IBS with Diarrhea 

49

IBS with constipation 

50

Lifestyle and Alternative medicine for IBS 

Avoid or reduce? 

4 other things 

51

Low FODMAPs Diet 

What does it stand for? 

What are they? 

What does this lead to? 

52

IBD

Chronic disease that causes? 

How does it begin? 

periods of? 

What is the goal of therapy? 

53

IBD 2 types 

  • Inflammation usually extends from the mucosa through the entire thickness of the bowel wall
  • Inflammation limited to the mucosa of the colon 
  • Inflammation limited to the colon 
  • Can affect any area of the GI tract from the mouth to the anus 
  • Thuse fistulas, abscesses or strictures of the bowel much less common 
  • Thus may lead to fistulas, abscesses or strictures of the bowel much less common 

54

Symptoms of IBD

Most common symptoms are? 

Other symptoms are? 

Inflammation outside the GI can cause? 

Children with the disease may have? 

55

IBD OTC tx 3 things 

56

Rx med for IBD 

57

Aminosalicylates 

58

Targeting Aminosalicylates 

59

Glucocorticoids 

60

Immunomodulators 

And methotrexate 

61

Anti-Tumor necrosis factor 

  •  

62

Anti-integrin 

63

Abx for IBS

64

Celiac Disorder 

___ - mediated intestinal disorder

Characterized by?

Predisposed? 

Dietart proteins in? 

65

Diagnosis of Celiac Disease

How does it present 

What type of testing? 

Biopsy where? 

66

Tx for celiac disease

Life long?

Initially?

Refractory disease?