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Flashcards in Herpes Deck (19):
1

Acyclovir?

Nucleoside DNA polymerase inhibitor 

2

Lamivudine 3TC 

As well as being used for HIV can also inhibit replication of?

Side or tide?

 

NRTI

HBV

3

How do nucleoside reverse transcriptase inhibitors cause termination of viral growth 

  • The lack of 3'-OH analog prevents the formation of the 5' to 3' phosphodiester linkage needed for chain elongation 

4

Oseltamivir blocks?

Neuraminidase

5

Ritonavir?

MOA

DI AE

 

  • Antiretroviral protease inhibitor 
  • Competitive inhibitor of HIV protease responsible for cleaving gag-pol precursor molecule
  • Inhibit both HIV-1 and 2 

DI

  • Ritonavir is a substrate and potent inhibitor of CYP3A4 
  • Can act as a pharmacokinetic enhancer of drug metabolized by CYP450 3A 

AE 

  • Hyperlipidemia, with large increases in total cholesterol and TG concentrations 

6

Penciclovir? Prodrug

MOA?

 

Nucleoside DNA pol inhibitor 

MOA is the same as Acyclovir but is retained in HSV infected cells for much longer 

It doesnt terminate the chain but inhibits DNA pol. 

Resistance can occur with loss of thymidine activity

7

Tenofovir?

Nucleotide RTI

8

Acyclovir must be phosphorylated intracellualarly by?

viral thymidine kinase 

9

Integrase inhibitors?

Raltegravir, prevent virus DNA from integrating into host genome

10

Acyclovir once converted to Acyclovir triphosphate does what?

More potent against?

Resistance can occur how?

Competitively inhibits viral DNA polymerase 

against HSV

Resistance due to lack of thymidine kinase activity 

11

Zidovundine ZDV or AZT is a?

Nucleoside ot tide?

NRTI

12

Maravoroc?

HIV entry inhibitor that stops binding with CCR5 receptor - Can interfere with immune response, not effective at all with CXCR4 because CCR5 isnt used

13

Foscarnet?

AE?

Indicated for treatment of?

 

Nonnucleoside DNA pol inhibitor 

treats acyclovir-resistant HSV, CMV retinitis 

Can cause seizures, renal function, headache, vomit, 

by IV only 

14

Cidofovir

Against what?

Synthetic?

AE

Administered?

NucleoTIDE DNA pol inhibitor 

Against CMV retinitis 

Synthetic Deoxyctidine phosphonate

Skips phosphorylation step 

Via IV

15

Ganciclovir 

How is it activated?

Primarily against?

Resistance?

Adverse effects?

 

phosphorylation by viral protein kinase pUL97

Nucleoside DNA pol inhibitor 

Primarily against CMV

Resistance by mutations in viral protein kinase and or viral pol gene

Black box warning granulocytopenia (neutropenia) and thrombocytopenia 

 

16

Zidovudine ZDV or AZT 

AE

  • Bone marrow toxicity causing anemia 
  • Lactic acidosis 

17

Acyclovir is primarily used against?

HSV and VZV 

18

Nevirapine, delavirdine and efavirenz are?

MOA

AE

  • NNRTI
  • They are not active against HIV-2 
  • NNRTIs bind directly noncompetitively to the RT enzyme at a site distinct from NRTI binding site 
  • Block DNA polymerase by causing a conformational change and disrupt the catalytic site of the enzyme 

19

Tipranavir 

 

  • Antiretroviral protease inhibitor 
  • non-peptidic protease inhibitor 
  • AE
    • Dose-dependent hepatotoxicity, lipodytrophy