What is an antigenic drift?
1) Due to point mutations in the coding regions of the hemagglutinin (HA) and Neuroaminidase (NA) proteins induced by the high error rate of viral RNA polymerase. Spontaneous mutation rate is 1 per genome per replication
Inhibitor of influenza neuraminidase, respiratory powder
Influenza is highly contagious why?
Because it infects the respiratory tract so when you cough it spreads and is inhaled
Influenza is know as what type of virus?
Swine flu was?
Amantadine is what type of inhibitor?
Antigenic changes such as drifts and shifts lead to what?
1) Resistance to existing drugs 2) Lack of recognition by host immunized against previous version of the virus
What does amantadine block?
Blocks the M2 proton ion channel
Epidemic that spreads over an entire continent
Oseltamivir is a?
Inhibitor of influenza neuraminidase oral
What is the natural host of influenza A?
Rimantadine is ___ compared to amantadine
What is the significance of the H and N in something like H1N1 For Influenza A-High mortality
What is an antigenic shift?
1) It is due to reassortment of different segments of the viral genome 2) Produces major changes in the antigenic character of the HA and NA molecules 3) Occurs in animal hosts infected by more than one type of influenza
Rimantadine is a?
Rimantadine is poor at crossing the? and has less what?
BBB CNS effects
Explain how Influenza gets into the cell and replicates
Influenza genome is divided into 8 linear RNA segments which can re-assort when?
Upon infection of the same cell with different types of virus