Endocytosis and Protein Degradation Flashcards Preview

M2M Unit III > Endocytosis and Protein Degradation > Flashcards

Flashcards in Endocytosis and Protein Degradation Deck (31):
1

The UPS is responsible for the ______.

rapid degradation of proteins

1

______ is typically described as a stress response to starvation; components of the cell are broken down to be _____.

Autophagy; reutilized for survival

2

Autophagy is typically described as______; components of the cell are _____ to be reutilized for survival.

a stress response to starvation; broken down

3

_____ is carried out by macrophages and neutrophils.

Phagocytosis

3

About ____ of protein synthesis occurs in the rough ER.

30%

3

A chain of at least ______ is required by the proteasome as a tag for degradation.

4 ubiquitins

5

_____ of vesicles involves small volumes.

Pinocytosis

7

Autophagy is mainly involved in the degradation of _____.

long-lived proteins and entire organelles

8

There are two major routes of endocytosis: (1)____ and (2) ______.

phagocytosis; pinocytosis

9

Pinocytosis of vesicles involves ____.

small volumes

10

What does UPS stand for?

ubiquitin-proteasome system (UPS)

11

There are two major routes of ______: (1)phagocytosis and (2) pinocytosis.

endocytosis

12

_____ are typically formed by two mechanisms, either clathrin coat proteins or caveolae.

Vesicles

12

Three major protein degradation pathways exist in eukaryotic cells: ______, _____, and ______.

the ubiquitin-proteasome system (UPS), the lysosome, ad autophagy

12

____ helps fold a protein by binding to exposed hydrophobic patches in incompletely folded proteins and prevents aggregation.

Hsp70

13

About 30% of protein synthesis occurs in the ____.

rough ER

14

_____ is mainly involved in the degradation of long-lived proteins and entire organelles.

Autophagy

15

_____ primarily degrade extracellular materials taken up by endocytosis and some intracellular components.

Lysosomes

17

Phagocytosis is carried out by _____ and _____.

macrophages; neutrophils

19

______ are small endocytic vesicles that form without coat proteins.

Caveolae

21

A chain of at least four ubiquitins is required by the _____ as a tag for degradation.

proteasome

22

Caveolae are small endocytic vesicles that form _____.

without coat proteins

23

Three major _____ pathways exist in eukaryotic cells: the ubiquitin-proteasome system (UPS), the lysosome, and autophagy.

protein degradation

24

Dynamin _____.

pinches off the membrane

25

Hsp70 helps fold a protein by _____ in incompletely folded proteins and prevents aggregation.

binding to exposed hydrophobic patches

26

____ forms an elaborate, large, barrel-shaped structure that acts as an isolation chamber. Misfolded proteins are fed into the chamber to prevent ______ and to help it to refold.

Hsp60; aggregation

27

Hsp60 forms an elaborate, large, _____ that acts as an isolation chamber. ______ proteins are fed into the chamber to prevent aggregation and to help it to refold.

barrel-shaped structure; Misfolded

28

The _____ is responsible for the rapid degradation of proteins.

UPS

29

_____ pinches off the membrane.

Dynamin

30

Vesicles are typically formed by two mechanisms, either ______ or ______.

clathrin coat proteins; caveolae

31

Lysosomes primarily degrade extracellular materials taken up by _____ and some _____.

endocytosis; intracellular components