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M2M Unit III > MS > Flashcards

Flashcards in MS Deck (36):
1

In MS, the speed of transmission is _____.

decreased

2

In MS, the latency is _____.

prolonged

3

What does Dalfampridine do?

blocks K+ channels and improves walking speed

4

Demyelination causes proliferation of _____ along the axons.

sodium channels

4

______ causes proliferation of sodium channels along the axons.

Demyelination

5

What is molecular mimicry?

different antigens may cause the same immune reaction if they are similar to each other

5

In MS, the ______ is prolonged.

latency

5

In MS, the amplitude of response is ______.

smaller

6

If you see contrast in the brain, you should think that ______.

the blood brain barrier has been disrupted

7

In MS, the _____ is decreased.

speed of transmission

8

Dawson's fingers

demyelination of the brain around the lateral ventricles causing distinct finger-like projections on imaging

8

What most often causes decreased quality of life in MS?

pain

9

The ____ MS is treated, the _____ the outcomes.

earlier; better

11

MS is _______ and ________.

progressive; degenerative

12

Genes related to MS do not cause the disease- they ______.

increase the susceptibility to getting MS

13

What does flecainide do?

it's a sodium channel blocker to preserve axons

14

What is the main underlying cause of MS?

demyelination

15

What is the lifetime risk for a Colorado resident with a first degree affected relative to get MS?

3%

16

What are the common symptoms of MS?

fatigue, walking impairment, spasticity, cognitive impairment, bladder dysfunction, pain, mood instability, sexual dysfunction

17

With ________ sodium entry into the cell, impulse conduction is slowed.

increased

19

How many lesions occur if no treatment is given?

about 5 per

20

In MS, the _______ of response is smaller.

amplitude

20

Name 2 drugs given to block sodium channels and preserve axons.

phenytoin and flecainide

21

Why does calcium-mediated nerve injury occur in demyelination?

the sodium-calcium exchange is reversed and calcium influxes into the cell

22

What does phenytoin do?

it's a sodium channel blocker to preserve axons

24

What virus is historically associated with MS?

Epstein-Barr virus

25

With increased sodium entry into the cell, nerve conduction is ______.

slowed

27

What is the clinical isolated symptom?

the first MS symptom affecting the pt

28

How could the blood brain barrier get disrupted?

an immunologic response; inflammation

30

How is walking impairment assessed?

timed foot walks

31

What is latency?

the time from signal to response

32

When does the 2nd relapse typically occur?

12-18 mos after the first

33

What happens in the preclinical phase of MS?

pts c/o muscle and cognitive fatigue

34

What is relapse?

onset of new deficits within a 24 hour period that persist for 2-3 weeks but slowly get better

35

There are over ____ genes directly related to MS.

100

36

MS patients have to use _____ neurons to do the same task as a non-patient.

20% more