Signaling and RTKs Flashcards Preview

M2M Unit III > Signaling and RTKs > Flashcards

Flashcards in Signaling and RTKs Deck (25):
1

Give an example of a lipophilic (hydrophobic) hormone.

Steroid hormones

1

Gefitinib blocks _____ and thus stops downstream signaling.

EGFR kinase activity

2

Give an example of a hydrophilic (lipophobic) hormone.

proteins/peptides/amino acids

3

____ is likely the most extensive node in signaling.

Ca2+

3

Most ______ target signaling molecules.

non-antibiotic drugs

3

Two major classes of signaling molecules are ____ and ____.

lipophilic (hydrophobic) and hydrophilic (lipophobic)

4

____ are points in a network that receive multiple inputs and/or multiple outputs.

Nodes

5

_____ is the target for Sildenafil.

PDE5

6

PDE5 is the target for ______.

Sildenafil

7

Endocrine signaling

hormone is circulated in the bloodstream

7

What drug is an anti-EGFR that blocks the ligand binding site?

cetuximab

8

Ca2+ is likely the most extensive ____ in signaling.

node

10

____ is NOT a second messenger; its signaling is not concentration dependent.

GTP

11

_____ blocks EGFR kinase activity and thus stops downstream signaling.

Gefitinib

13

Most non-antibiotic drugs target  ______.

signaling molecules

14

Contact-dependent signaling 

the mediator is membrane-bound

15

Autocrine signaling

the receptor is on the same cell that sent the signal

17

Nodes are points in a network that _____.

receive multiple inputs and/or multiple outputs

18

_____ are groups of components (or building blocks) that function together.

Modules

19

Synaptic signaling

neurons use neurotransmitters to signal nearby cells

21

______ are membrane-bound switches that are regulated by GAPs and GEFs

Ras proteins

22

cetuximab

anti-EGFR that blocks the ligand binding site

23

Ras proteins are membrane-bound switches that are regulated by ____ and ____.

GAPs; GEFs

24

Modules are groups of components (or building blocks) that _____.

function together

25

Paracrine signaling

target cells are nearby