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M2M Unit III > Epithelial Transport > Flashcards

Flashcards in Epithelial Transport Deck (51)
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1

At rest, the apical _____ channels are closed.

Cl-

1

What kinds of metabolic waste molecules are non-volatile?

urea and protons

2

_____ cannot maintain large energy gradients because solutes and water leak back across the epithelium through the pericellular shunt.

Leaky epithelia

2

In the lungs, ____ diffuses passively from blood to air.

CO2

3

How does someone get cystic fibrosis?

it's genetic

3

How do the kidneys filter waste?

the epithelial cells lining the tubules reabsorb the things that it wants to keep (glucose, salts, bicarbonate, etc)

4

Each day the cells in an adult human produce about ____ of metabolic waste solute.

15 moles

4

What is Uremia?

urine in the blood

4

Functions of the kidney include excreting non-volatile metabolic wastes and _____.

regulating the composition of virtually all ECF solutes as well as water

5

By keeping the ______ concentration low, the Na/K pump provides the energy to drive a host of secondary transporters.

intracellular sodium ion

5

How are the metabolic waste solutes removed from the body?

fluid exits the lungs; the kidneys do the rest

6

Synonyms for _____ include serosal and peritubular.

basolateral

7

Where are water pumps located in the body?

they don't exist

8

What is the defect in cystic fibrosis?

the Cl- channel is mutated, reducing the epi's ability to secrete serous fluid, causing very thick mucous and infections

9

What does CFTR stand for?

Cystic Fibrosis Transmembrane Conductance Regulator

10

In general, epithelia engaged in _____ are leaky, while those epithelia doing the finishing work are tight.

massive transport of substances

10

A ____ transepithelial voltage would be measured in leaky tight junctions.

lower

11

By keeping the intracellular sodium ion concentration ____, the Na/K pump provides the energy to drive a host of secondary transporters.

low

13

In general, epithelia engaged in massive transport of substances are leaky, while those epithelia _____ are tight.

doing the finishing work

13

How are the GI tract epithelium transporters regulated?

they aren't- they will absorb everything ingested

14

Water always moves passively down _____.

osmotic gradients

15

What is the equation for transepithelial potential difference (transPD)?

TransPD = Vm (Basolateral) – Vm (Apical)

15

How does cholera toxin work?

it locks open the Cl- channels, causing a massive efflux of fluid from the cell

15

Water always moves _____ down osmotic gradients.

passively

17

The _____ is always located on the basolateral membrane.

Na/K pump

18

Synonyms for _____ include mucosal and luminal.

apical

20

What is the key player in secretion of fluid by an epithelial cell?

the Cl- channel

21

The ____ and _____ are examples of sodium-dependent secondary active transport systems.

sugar; amino acid pumps

22

The sugar and amino acid pumps are examples of ______.

sodium-dependent secondary active transport systems

23

Functions of the ____ include excreting non-volatile metabolic wastes and regulating the composition of virtually all ECF solutes as well as water.

kidney