The defining morphological feature of _____ is a collapse of the nucleus.
What is lymphoproliferative syndrome?
an autoimmune disease where apoptosis fails to occur
Fragmentation of DNA seen in apoptosis is via an _____ that produces up to 300,000 ds DNA breaks per chromosome.
_____ and _____ result in the classic appearance of apoptosis.
Why are lymphocytes so sensitive to radiation?
So they will kill themselves rather than multiply if damaged and possibly result in autoimmunitiy
Inflammatory molecules attract WBCS, primarily _____.
A ______ consists of a core of histone proteins wrapped by about 180 base pairs of DNA.
FLIP competes with caspase-8 for binding to ____, and this inhibits apoptosis signaling.
All the _____ in a normal plasma membrane is confined to the inner leaflet of the lipid bilayer.
____ and ____ are pro-apoptotic proteins that replace Bcl-2 and Bcl-XL when the suicide signal is received.
_______ in the cytoplasm activates a cytoplasmic protein called Apaf-1.
In the other CTL mechanism, the ____ secretes granzymes and perforin that together deliver apoptosis-inducing molecules to its intended target.
Many experts estimate that it takes about 7 mutations for a cell to become ______.
fully, clinically, malignant
FLIP competes with _____ for binding to FADD, and this inhibits apoptosis signaling.
A nucleosome consists of a core of histone proteins wrapped by about ____ of DNA.
180 base pairs
What enzyme distributes PS equally on both sides of the membrane during apoptosis?
Bax makes the _____ permeable and cytochrome C is released into the cytoplasm.
A _____ that recognizes a cell as apoptotic does not become activated.
boiling action of the plasma membrane
In the other CTL mechanism, the killer cell secretes ______ and ______ that together deliver apoptosis-inducing molecules to its intended target.
Bcl-2 and Bcl-XL are _____ on the mitochondrial membrane.
A nucleosome is the ______ of DNA.
first stage of compaction
Apaf-1 activates the protease caspase-9, and it activates _____.
What activates capsase-3 in the intrinsic pathway?
small pieces of the cell
FLIP competes with caspase-8 for binding to FADD, and this inhibits _____.
____ activates the protease caspase-9, and it activates caspase-3.
Apaf-1 activates the protease ____, and it activates caspase-3.
If a molecule of PS strays to the outer leaflet, ____ returns it to the correct position.
Cytochrome C in the cytoplasm activates a cytoplasmic protein called ____.