Epithelial tissue Flashcards

1
Q

how many functions of skin are there

A

7

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2
Q

name all functions of skin

A

protection
containment
thermoregulation
immunological defences
sensory abilities
communication
appendages

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3
Q

describe protection (functions of skin)

A

skin resists abrasion and penetration
blocks entry of foreign material, pathogens, UV rays

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4
Q

describe containment (functions of skin)

A

skin prevents loss of body fluids
skin is waterproof

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5
Q

describe thermoregulation (functions of skin)

A

controls transfer of heat across body’s surface
facilitates heat retention and dissipation (sweat and temp regulation)

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6
Q

describe sensory abilities (functions of skin)

A

sensations
touch
hair (air between hair keeps you warm)

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7
Q

describe communications (functions of skin)

A

skin releases visual and pheromone signals

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8
Q

describe appendages (functions of skin)

A

hair
nails
sebaceous glands
sweat glands

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9
Q

ALL EPITHELIAL TISSUE…

A

RESTS ON A BASEMENT MEMBRANE

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10
Q

what is basal lamina

A

basement memebrane

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11
Q

what doesn’t H&E stain

A

the BM
can only see it sometimes depends on plane of section (can see more clear in hair and respiratory tract)

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12
Q

what is only below the BM

A

blood vessels and extracellular space

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13
Q

name the layers of skin

A

epidermis
dermis
hypodermis

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14
Q

name the stratums (BM and up)

A

stratum corneum
stratum granulosum
stratum spinosum
stratum germinativum

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15
Q

describe stratum germinativum

A

layer of columnar cells resting on BM
stem cells - can divide and become themselves or differentiate to layer above
growth is apical (apical level used to name tissue)

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16
Q

describe stratum spinosum

A

polygonal shape cells
between cells = spines = desmosomes which connect cells together

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17
Q

describe stratum granulosum

A

cells are becoming flat
have keratohyalin granules that produce keratin
~ 30 day turnover, makes granules, bursts and gives next stratum

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18
Q

describe stratum corneum

A

stratified squamous keratinized
cells explode and form keratin sheets

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19
Q

what does covering epithelia mean

A

covers body and organs

20
Q

name all types of tissue (epithelia)

A

simple squamous
simple cuboidal
simple columnar
stratified squamous (keratinized and non keratinized)
transitional
pseudostratified columnar
glandular epithelia

21
Q

what does lamina propria mean

A

generally describe connective tissue

22
Q

describe simple tissues

A

squamous = one layer flat cells
cuboidal = one layer cube shaped cells
columnar = more tall than wide, could have cilia

the way it looks depends on PLANE OF SECTIONNNNN

23
Q

describe transitional epithelium

A

covers bladder - cells expand with it
changes shape often

24
Q

describe pseudostratifed columnar

A

pseudo = fake, looks stratified but is simple
found in respiratory tract
goblet cells!

25
Q

describe staining of BM

A

glucose moiety + periodic acid = aldehyde moiety
PAS reaction
red/fuchsia stain
can see BM

26
Q

describe composition of BM

A

proteoglycans
glycoproteins
collagen
layer of reticular fibers (underlies BM)

27
Q

describe proteoglycans

A

look like test tube brush cleaner
protein core
50/50 sugar and proteins
glycosaminoglycans = GAGs

28
Q

describe GAGs

A

negatively charged and hold water

29
Q

give ex of proteoglycans

A

heparan sulphate - synthesized by epithelial cells

30
Q

describe glycoproteins

A

10% sugars and 90% protein
protein backbone
3 sugars and modified sugar at end

31
Q

name types of glycoproteins (3)

A

laminin
Nidogen-1 (Enactin)
Fibronectin

32
Q

describe laminin (glycoproteins)

A

cross shaped
links surface of epithelial cells to BM (helps it stick)

33
Q

describe Nidogen-1 (Enactin) (glycoproteins)

A

small glycoprotein
essential component for BM

34
Q

describe fibronectin (glycoproteins)

A

adhesive that binds plasma membrane of epithelial cells to heparan sulphate - like glue

35
Q

describe collagen

A

part of ECM
stains bright pink

36
Q

name and describe collagens of BM

A

type IV = synthesized by epithelial cells
type VII = anchoring filaments (filaments/fibers and anchors)
type III - reticular fibers

37
Q

how many functions of BM are there

A

5

38
Q

name all functions of BM

A

1 - structural attachment
2 - compartmentalization
3 - filtration
4 - maintain polarity
5 - tissue scaffolding

39
Q

describe structural attachment (functions of BM)

A

attachment of epithelial cells to connective tissue

40
Q

describe compartmentalization (functions of BM)

A

isolate epithelial cells and muscle cells (tissue types)
bundle and separate stuff

41
Q

describe filtration (functions of BM)

A

movement of molecules is partly regulated by ionic charges
important for kidneys (filtration mechanism)

42
Q

describe helps maintain polarity (functions of BM)

A

how cells know basal membrane from apical layers

if they don’t know which way is up then they keep dividing and causes problems like skin cancer (when polarity is off)

intermediate filaments = no polarity

43
Q

describe tissue scaffolding (functions of BM)

A

helps to scaffold regeneration
need BM to generate and stabilize cells and create upper layers

44
Q

name and describe all characteristics of epithelial tissues (6)

A

1- cells are closely associated with little extracellular space
2 - cells are strongly attached via intracellular junctions
3 - lines body surfaces and cavities
4 - specialization - absorption, secretion, sensation and contractility - depends on where tissue is found
5 - cells are polarized
6 - epithelial tissues rest on A BASEMENT MEMBRANE

45
Q

what is a scar

A

regrowing BM
discolouration due to melanocytes