Lab 11: Kidney Flashcards

1
Q

functions of kidney

A

urine formation
regulation of blood pressure regulation of blood volume
regulation of a/b balance
formation and release of hormones

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2
Q

describe blood flow in kidney

A

renal artery –> interlobular artery –> arcuate artery –> interlobular artery –> afferent arteriole –> glomerulus –> efferent arteriole

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3
Q

are collecting tubules part of nephron

A

NOOOO

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4
Q

describe cortex

A

notice outer layer or capsule of kidney
medullary rays visible
renal corpuscles in cortex

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5
Q

name parts of renal corpuscle

A

bowmans capsule
vascular pole
urinary pole

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6
Q

name and describe layers of bowmans capsule

A

parietal layer = outer, simple squamous epithelium
visceral layer = inner, made of podocytes (and pedicels - not visible)

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7
Q

describe vascular pole (of renal corpuscle)

A

where blood vessels enter

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8
Q

describe urinary pole (of renal corpuscle)

A

where glomerular filtrate exits via proximal convoluted tubule

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9
Q

name cortical tubules

A

PCT = proximal convoluted tubule
DCT = distal convoluted tubule

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10
Q

describe proximal convoluted tubule

A

darker staining
cells have striated appearance due to folding of PM around mitochondria
brush border due to microvilli (improves absorption)
central nuclei
cloudy lumen

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11
Q

describe distal convoluted tubule

A

cells are less acidophilic
apically located nucleus
relatively clean lumen

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12
Q

what is common for both PCT and DCT

A

cannot delineate lateral membranes

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13
Q

what are 2 layers of bowmans capsule separated by

A

bowmans space
between visceral and parietal layers

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14
Q

what are medullary rays

A

at center of each lobule = striated projections of medulla into cortex

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15
Q

name parts of medullary rays

A

collecting tubule
thick descending limb of loop of henle
thick ascending limb of loop of henle

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16
Q

describe collecting tubule (medullary rays)

A

cuboidal cells
Visible lateral membranes
not part of nephron

17
Q

describe thick descending limb of loop of henle
(medullary rays)

A

similar to PCT

18
Q

describe thick ascending limb of loop of henle
(medullary rays)

A

similar to DCT

19
Q

name parts of juxtaglomerular apparatus

A

macula densa
juxtaglomerular cells
extraglomerular mesangial cells

20
Q

describe macula densa of juxtaglomerular apparatus

A

part of DCT that comes close to afferent arteriole
large columnar cells

21
Q

describe juxtaglomerular cells of juxtaglomerular apparatus

A

hard to see cells of afferent arteriole that contact macula densa
secretes hormone containing granules - secretes renin

22
Q

describe extraglomerular mesangial cells of juxtaglomerular apparatus

A

cannot distinguish

23
Q

describe medulla parts

A

thick limbs
thin limbs (only in medulla)
collecting ducts
area cribosa (opening of collecting ducts)

24
Q

name parts of upper medulla

A

collecting ducts
thick descending and ascending limbs of loop of henle

25
Q

describe collecting ducts of bellini of medulla

A

collecting tubules drain into these
Similar appearance
very visible lateral membranes
site of ADH/vasopressin activity

26
Q

describe thick descending and ascending limbs of loop of henle of upper medulla

A

same appearance as in medullary rays

27
Q

describe lower medulla

A

numerous collecting ducts of bellini
thin limb of loop of henle

28
Q

describe thin limb of loop of henle of lower medulla

A

similar appearance to capillary except capillary contains plasma cells (red)
thin limb appears empty

29
Q

describe medulla

A

paler staining than cortex
striated appearance
no renal corpuscle
vasa recta = capillaries branching from efferent arteriole

30
Q

describe area cribosa

A

at apex of the medullary pyramids = urine from collecting ducts drain into area cribosa then goes into minor calyx –> major calyx –> ureter –> urinary bladder (stored here)

31
Q

describe mucosa of urinary bladder

A

transitional epithelium with facet/dome cells

32
Q

describe submucosa of urinary bladder

A

dense irregular CT

33
Q

describe tunica muscularis of urinary bladder

A

3 layers of smooth muscle = inner longitudinal, middle circular, outer longitudinal

34
Q

describe dome cells of urinary bladder

A

can distend and look squamous when bladder is full
looks cuboidal/columnar when bladder is empty