Estrogen-Progestin HRT

Question 1

Therapeutic Class

Answer 1

combination hormone replacement therapy

Question 2

Examples

Answer 2

conjugated estrogen w/medroxyprogesterone (Prempro)

Question 3

Mechanism of Action

Answer 3

Estrogens bind to nuclear receptors in estrogen-responsive tissues. Circulating estrogens impact pituitary secretion of gonadotropins, LH & FSH, through negative feedback. Estrogens act to reduce elevated levels in postmenopausal women.

Question 4

Actions and Uses

Answer 4

Moderate to severe vasomotor symptoms of menopause; vulvar/vaginal atrophy
Prevention of postmenopausal osteoporosis

Question 5

Adverse Effects

Answer 5

Abdominal pain, back pain, headache, nausea, depression, pruritus, thromboembolism, neoplasm, angioedema

Question 6

Black Box Warning

Answer 6

Endometrial cancer, breast cancer, CV disorders

Question 7

Contraindications

Answer 7

Undiagnosed post-menopausal bleeding, ER or PR sensitive tumors, thromboembolic disorders, hepatic impairment

Question 8

Interactions

Answer 8

erythromycin, clarithromycin, ketoconazole, itraconazole, ritonavir, phenobarbital, carbamazepine, rifampin, St. John’s wort

Question 9

Preg Cat

Answer 9

x