Prostaglandin Flashcards
(8 cards)
1
Q
Therapeutic Class
A
cervical ripening
2
Q
examples
A
dinoprostone (Cervidil) E2 (PGE2)
3
Q
Mechanism of Action
A
in pregnancy, PGE2 secreted continuously by fetal membranes and placenta
Plays important role in final events leading to initiation of labor
PGE2 stimulates PGF2 alpha leads to sensitizes myometrium to oxytocin
PGE2 also ripens cervix
- marked relaxation of cervical smooth muscle fibers
4
Q
Actions and Uses
A
- vaginal insertion for 12 H
- At or near term pregnancy
5
Q
Adverse Effects
A
-uterine hyperstimulation, fetal distress
6
Q
Black Box Warning
A
Uterine rupture, postpartum DIC
7
Q
Contraindications
A
-Fetal distress, unexplained vaginal bleeding, previous cesarean section, history major uterine surgery, rupture of membranes
8
Q
Preg Cat
A
C
