Transdermal Contraceptive Patch

Question 1

Therapeutic Class

Answer 1

combination extended use contraceptive

Question 2

Example

Answer 2

ethinyl estradiol& norelgestromin (Ortho-Evra)

Question 3

Mechanism of Action

Answer 3

Inhibit release of FSH & LH preventing ovulation

Question 4

Actions and Uses

Answer 4

Transdermal Contraception
1 patch/week x 3 weeks, followed by patch-free week
improve menstrual cycle regularity, decreases incidence of dysmenorrhea

Question 5

Adverse Effects

Answer 5

Skin irritation (teach to rotate sites)
DVT, PE, CVA, MI
Concern of reduced absorption as BMI increases

Question 6

Black Box Warning

Answer 6

Cigarette smoking increases risk of CV adverse effects, risk increases > 35y/o & heavy smoking > 15 cigarettes/day

Question 7

Contraindications

Answer 7

Thromboembolic disorders, stroke, coronary artery disease, hepatic tumors; carcinoma of breast, uterus or ER or PR dependent tumors, pregnancy

Question 8

Interactions

Answer 8

Decreased efficacy: rifampin, antibiotics, barbiturates, anticonvulsants, protease inhibitors, antifungals
Breakthrough bleeding: St. John’s wort

Question 9

Preg Cat

Answer 9

x