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601

What do diuretics do?

decrease volume

602

What do Beta-Blockers do?

Limit sympathetic stimulation to heart, hold heart rate down

603

What agents increase cardiac muscle contraction?

Digitalis (Glycosides)

604

How do digitalis (glycosides) work?

1. inhibit NA/K pump, increase intracellular Ca++
2. Increases cardiac outpu
3. Low therapeutic window
4. Signs of digitalis toxicity (N/V, headache, confusion, arrhythmias, sinus bradycardia)

(** recently fallen out of favor)

605

Name 2 other treatments to adjust cardiac muscle contraction?

1. ventricular assist
2. heart transplant

606

Most clinical measures of cardiac function correlate ______ with clinical severity of HF

poorly

607

EX intolerance in CHF depends on 3 variables:

1. Disease
2. Level of inactivity
3. Other

608

Measurements of EX capacity in HF include:

1. peak oxygen uptake
2. anaerobic threshold

609

Peak VO2

610

6 MWT predicts?

VO2

611

For the 6 MWT, 40% who walke

612

Acute CARDIAC responses to EX in pts w/ HF = progressive _______ in cardiac output, stroke volume, and HR reserve capacity. EX tolerance is limited by reduced __________________________.

decrease
CO during EX.

613

Acute CIRCULATORY responses to EX in pts w/ HF: muscle blood flow is ________ during an acute bout of EX in pts with HF.
Not entirely due to a reduction in _____________ or ________________. Change in the distribution of _____________ during EX.

-reduced
-CO or local vascular impairment
-blood flow

614

Acute SKELETAL MUSCLE METABOLIC responses to EX in pts w/ HF: higher _______ levels at submaximal workloads. Slower on-and-off _________ w/ Ex

lactate
kinetics