Exam 3 - Hazbun Flashcards
COPD is associated with
a. TH1
b. TH2
a. TH1
asthma is associated with
a. TH1
b. TH2
b. TH2
what does alpha-1 antitrypsin do?
inhibits neutrophil elastase and limits lung tissue damage
genetic deficiency of alpha-1-anti-trypsin effects: which allele results in worse lung function?
ZZ allele
genetic deficiency of alpha-1-anti-trypsin effects: which allele results in increased height and respiratory function?
PI-MZ allele
alpha-1-antitrypsin deficiency 2 outcomes
-increased neutrophil migration
-increased lung damage via inflammation and protease activity
what is EVALI?
E-cigarette/Vaping product use associated lung injury
what is NETosis?
when neutrophils can kill pathogens extracellularly by releasing neutrophil extracellular traps (NETs)
cystic fibrosis results from mutations in the gene for the __________ ? (5 words)
cystic fibrosis transmembrane conductance regulator
cystic fibrosis patients secrete extremely viscous mucus that: (3 things)
-obstructs airflow in the lungs
-harbors pathogens leading to lung infections
-obstructs the pancreatic duct and interferes with digestion
the cystic fibrosis transmembrane conductance regulator is what kind of transporter? And it functions as what channel?
ABC transporter, calcium channel
CFTR is expressed where? (3)
-airway epithelium
-sweat duct epithelium
-pancreatic duct epithelium
loss of CFTR function causes increased ___ concentration in sweat glands
Na+
what year did the NIH start to recognize asthma as a chronic inflammatory disease and recommended corticosteroid therapy?
1991
which are typically used as “rescue” medications to provide quick relief of asthma symptoms?
a. LAMAs
b. LABAs
c. SABAs
d. LTRAs
c. SABAs
