Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

PHRM 825 Therapeutics > Final Exam - Dermatology > Flashcards

Final Exam - Dermatology Flashcards

(63 cards)

Start Studying
1
Q

what patients are at highest risk for dry skin (xerosis)

a. kids under 5
b. kids from 5-10
c. adults aged 20-30
d. elderly patients

A

d. elderly patients

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

emollients are the ____ line for itching associated with dry skin (xerosis)

A

first

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

4 agents to reduce itching for dry skin

A

-menthol and camphor
-pramoxine
-aluminum acetate
-hydrocortisone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

true or false: aluminum acetate alters C-fiber nerve transmission

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

dermatitis occurs ____ to ____ hours after exposure to poison ivy

A

24 to 48

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

treatment of acute dermatitis: avoid ___ _____ because they do not provide tx for long enough period of time

A

dose packs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

true or false: for acute dermatitis we should start with prednisone 10-20 mg per day

A

false (40-60 mg)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

atopic dermatitis is the most common form of _____

A

eczema

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the atopic triad?

A

-atopic dermatitis
-asthma
-allergic rhinitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

2 common triggers for atopic dermatitis (they were in bold)

A

detergents
infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

for moderate to severe atopic dermatitis, we can use ____-potency TCS BID for up to 3 days beyond clearance of lesions

A

medium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what is occlusion?

A

blockage or closing of an opening, blood vessel, or hollow organ

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

true or false: topical corticosteroids can cause tachyphylaxis

A

true

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

betamethasone dipropionate OINTMENT is in which class of topical corticosteroids?

A

very high potency (class 1)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

betamethasone dipropionate CREAM is in which class of topical corticosteroids?

A

high potency (class 2)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

betamethasone dipropionate LOTION is in which class of topical corticosteroids?

A

mid potency (classes 3-5)

(mid potency is where most patients start therapy)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

why shouldn’t you use betamethasone dipropionate ointment on the face?

A

due to vasoconstriction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

topical calcineurin inhibitors MOA

A

blocks pro-inflammatory cytokine genes

(can be used on any area)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

topical calcineurin inhibitors are now consideted ____-line tx, and long-term use can cause risk of respiratory infection in children < ____ years old

A

2nd; 2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

crisaborole 2% ointment is an alternative to TCS and TCIs. What is its MOA?

A

PDE-4 inhibitor (non-steroidal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

dupilumab (dupixent) MOA for mod-severe atopic dermatitis

A

human monoclonal antibody against IL-4 receptor alpha; inhibits signaling of IL-4 and IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

upadacitinib (Rinvoq) MOA

A

JAK inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how should Rinvoq be dosed?

A

15 mg to 30 mg PO once daily

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

ruxolitinib (Opzelura 1.5% cream) is for mild to moderate atopic dermatitis. What is its MOA?

A

JAK inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
____ have more severe acne during puberty a. males b. females
a. males
26
____ have more severe acne during adulthood a. males b. females
b. females
27
acne affects ___% of the adolescent population which corresponds to increased _____ production
90; androgen
28
what is comedone?
hair follicle plugged with sebum, keratin & dead skin
29
first choice for comedonal, noninflammtory acne (mild) a. adapalene + benzoyl peroxide b. oral isotretinoin c. topical retinoids
c. topical retinoids (especially adapalene)
30
first choice for mild-moderate papulopustular inflammatory acne (2 of them)
adapalene + benzoyl peroxide clindamycin + benzoyl peroxide
31
first choice tx for severe papulopustular or moderate nodular acne, and for nodular or conglobate acne
oral isotretinoin
32
MOA for adapalene (2)
-retinoid -regulate epithelia cell growth
33
MOA for tazorotene and tretinoin topical
retinoid
34
MOA for azelaic acid topical therapy (2)
-antibacterial -keratolytic (azelaic acid is adjunct)
35
MOA for benzoyl peroxide (3)
-antibacterial -comedolytic/keratolytic -anti-inflammatory
36
MOA for clindamycin, erythromycin, and clindamycin + BP topical therapy
topical antibiotic
37
true or false: we need to worry about tolerance for topical antibiotics
false (only have to worry about tolerance for oral antibiotics)
38
oral antibiotics for acne such as minocycline, doxycycline, erythromycin, azithromycin, and SMX/TMP are most effective when ______ is present
inflammation
39
limit treatment of oral antibiotics for acne to ___-___ weeks, if possible
6-8 weeks
40
oral hormone treatment for acne
spironolactone 100-150 mg per day (suppresses androgen production)
41
clascoterone 1% cream is an androgen receptor inhibitor for acne and is applied how often per day?
BID
42
isotretinoin is a vitamin ___ derivative
A
43
isotretinoin can only dispense a ___ day supply with no refills
30
44
what is telangiectasia? (common in rosacea)
small widened blood vessels on the skin (permanent dilation of the blood vessels)
45
who is more likely to have rosacea, men or women?
women
46
hydralazine is a ____ that can be a trigger for rosacea
vasodilator
47
topical meds for rosacea should be allowed to penetrate the skin for ___-___ min before applying makeup
5-10
48
example of a topical antibiotic for mild rosacea
metronidazole (apply BID)
49
for rosacea, patients should minimize ___ exposure
sun
50
psoriasis results from rapid skin growth that is ___ times faster than normal
7
51
3 major types of psoriasis
plaque scalp psoriatic
52
severe psoriasis classification is > ____% BSA
10
53
how do keratolyics such as salicylic acid 2% treat psoriasis?
causes slothing of the very dry scales
54
true or false: completely avoid sun exposure to treat psoriasis
false (can be beneficial, but not up to the point where it causes burns)
55
calcipotriene/calcitriol are both vitamin ___ analogs
D
56
high/very-high potency topical corticosteroids for psoriasis should be limited to no more than ____ grams per week
50
57
phototherapy for psoriasis is for ____ and ____ plaques
limited; resistant
58
which penetrates thicker lesions better in phototherapy for psoriasis: UVA or UVB
UVA
59
apremilast MOA for psoriasis
PDE-4 inhibitor
60
azothiaprine, methotrexate, and mycophenolate mofetil MOA for psoriasis
immunosuppressants
61
cyclosporine MOA for psoriasis
calcineurin inhibitor
62
tofacitinib MOA for psoriasis arthitis
JAK inhibitor
63
avoid use of ____ vaccines in treatment with biologic agents for psoriasis
live

PHRM 825 Therapeutics (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions