Final Exam - Nausea and Vomiting Flashcards
nerve stimulation (ex. ReliefBand) helps the stomach return to a normal rhythym of ___ cycles/min
3
MOA of antihistamines and anticholinergics for N/V (ex. Meclizine, dimenhydrinate, scopolamine)
blocks histamine and/or muscarinic receptors in CTZ/NTS
MOA of phenothiazines for N/V (ex. prochlorperazine, promethazine)
dopamine receptor inhibition in CTZ
MOA of serotonin antagonists
serotonin inhibition at CTZ, vC, and GI tract
MOA of neurokinin-1 antagonists (ex. aprepitant, fosaprepitant, rolapitant)
neurokinin receptor inhibition at CTZ, VC, and GI tract
(centrally and peripheral)
MOA for buterophynones (ex. haloperidol, droperidol)
dopamine receptor inhibiton in CTZ
MOA for metoclopramide
dopamine receptor inhibition in CTZ; serotonin inhibition at high dose
MOA for cannabinoids (ex. dronabinol, nabilone)
binds with cannabinoid or CB1 receptors in brain
MOA for corticosteroids for N/V (ex. dexamethasone)
inhibition of cortical input into VC
MOA of thienobenzodiazepine for N/V (ex. olanzapine)
dopamine and serotonin receptor inhibition in CTZ
which has the longest duration of action?
a. ondansetron
b. granisetron
c. dolasetron
d. palonosetron
d. palonosetron (half life = 40 hours)
(no PO dosage form)
take dimenhydrinate 50 mg and meclizine 25 mg ___-___ min before needed
30-60
(prevention only)
post-op N/V is more common in
a. males
b. females
b. females
when are drugs administered for prophylaxis of PONV?
at end of procedure
aprepitant for PONV is given ___ mg orally ___ to ___ hours prior to induction of anesthesia
40; 1 to 3
