FA-pathology Neoplasias Flashcards Preview

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Flashcards in FA-pathology Neoplasias Deck (23):
1

What is the gene product of ALK and what is the associated gain of function neoplasm

Receptor tyrosine kinase; lung adenocarcinoma

2

What is the gene production of BCR-ABL and what is the associated gain of function neoplasm

Tyrosine kinase; CML, ALL

3

What is the gene production of BCL-2 and what is the associated gain of function neoplasm

Antiapoptotic molecule; follicular and diffuse large B cell lymphoma

4

What is the gene production of BRAF and what is the associated gain of function neoplasm

Serine/threonine kinase; melanoma, nonhodgkin lymphoma, papillary thyroid carcinoma

5

What is the gene production of c-KIT and what is the associated gain of function neoplasm

Cytokine receptor; gastrointestinal stromal tumor (GIST)

6

What is the gene production of c-Myc and what is the associated gain of function neoplasm

Transcription factor; bri kit lymphoma

7

What is the gene production of HER2/neu and what is the associated gain of function neoplasm

Receptor tyrosine kinase; breast and gastric carcinomas

8

What is the gene production of JAK2 and what is the associated gain of function neoplasm

Tyrosine kinase; chronic myeloproliferative disorders

9

What is the gene production of KRAS and what is the associated gain of function neoplasm

GTPase; colon cancer, lung cancer, pancreatic cancer

10

What is the gene production of MYCL1 and what is the associated gain of function neoplasm

Transcription factor; lung tumor

11

What is the gene production of MYCN and what is the associated gain of function neoplasm

Transcription factor; neuroblastoma

12

What is the gene production of RET and what is the associated gain of function neoplasm

Receptor tyrosine kinase; MEN 2A and 2B, medullary thyroid cancer

13

What is the gene production of APC and what is the associated loss of function neoplasm

Negative regulatory of beta-catenin/WNT pathway; colorectal cancer (associated with FAP0

14

What is the gene production of BRCA1/BRCA2 and what is the associated loss of function neoplasm

DNA repair protein; breast, ovarian, and pancreatic cancer

15

What is the gene production of CDKN2A and what is the associated loss of function neoplasm

P16, blocks G1 to S phase; melanoma, pancreatic cancer

16

What is the gene production of DCC and what is the associated loss of function neoplasm

DCC (deleted in colon cancer); colon cancer

17

What is the gene production of MEN1 and what is the associated loss of function neoplasm

Menin

18

What is the gene production of PTEN and what is the associated loss of function neoplasm

Tyrosine phosphatase of PIP3; breast cancer, prostate cancer, endometrial cancer

19

What is the gene production of Rb and what is the associated loss of function neoplasm

Retinoblastoma, osteosarcoma

20

What is the gene production of TSC1 and what is the associated loss of function neoplasm

Hamartin protein; Tuberous sclerosis

21

What is the gene production of TSC2 and what is the associated loss of function neoplasm

Tuberin protein; tuberous sclerosis

22

What is the gene production of VHL and what is the associated loss of function neoplasm

Inhibits hypoxia inducible factor 1a; von nipple Lindau disease

23

Detrusor overactivity leads to what?

Urge incontinance